FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1735842881> ?p ?o ?g. }

• W1735842881 endingPage "1870" @default.
• W1735842881 startingPage "1857" @default.
• W1735842881 abstract "Bilirubin and biliverdin possess antioxidant and anti-inflammatory properties and their exogenous administration protects against the effects of inflammation and trauma in experimental models. Despite the therapeutic potential of bile pigments, little is known about their in vivo parenteral or enteral absorption after exogenous administration. This study investigated the absorption and pharmacokinetics of bile pigments after i.v., i.p. and intraduodenal (i.d.) administration in addition to their metabolism and routes of excretion.Anaesthetized Wistar rats had their bile duct, jugular and portal veins cannulated. Bile pigments were infused and their circulating concentrations/biliary excretion were measured over 180 min. KEY RESULTS After i.v. administration of unconjugated bilirubin, biliverdin and bilirubin ditaurate, their plasma concentrations decreased exponentially over time. Subsequently, native and metabolized compounds appeared in the bile. When administered i.p., their absolute bioavailabilities equalled 14.0, 16.1 and 33.1%, respectively, and correspondingly 38, 28 and 34% of the same bile pigment doses were excreted in the bile. Administration of unconjugated bilirubin and bilirubin ditaurate i.d. increased their portal and systemic concentrations and their systemic bioavailability equalled 1.0 and 2.0%, respectively. Correspondingly, 2.7 and 4.6%, of the doses were excreted in the bile. Biliverdin was rapidly metabolized and these products were absorbed and excreted via the urine and bile.Bile pigment absorption from the peritoneal and duodenal cavities demonstrate new routes of administration for the treatment of inflammatory and traumatic pathology. Oral biliverdin administration may lead to the production of active metabolite that protect from inflammation/complement activation." @default.
• W1735842881 created "2016-06-24" @default.
• W1735842881 creator A5007936747 @default.
• W1735842881 creator A5008581557 @default.
• W1735842881 creator A5023851695 @default.
• W1735842881 creator A5062798808 @default.
• W1735842881 creator A5066801642 @default.
• W1735842881 creator A5089371574 @default.
• W1735842881 date "2011-11-15" @default.
• W1735842881 modified "2023-10-05" @default.
• W1735842881 title "Bile pigment pharmacokinetics and absorption in the rat: therapeutic potential for enteral administration" @default.
• W1735842881 cites W1522366213 @default.
• W1735842881 cites W1684644586 @default.
• W1735842881 cites W1940321413 @default.
• W1735842881 cites W1966582616 @default.
• W1735842881 cites W1968911405 @default.
• W1735842881 cites W1970465199 @default.
• W1735842881 cites W1970758290 @default.
• W1735842881 cites W1973508425 @default.
• W1735842881 cites W1992475433 @default.
• W1735842881 cites W1998861334 @default.
• W1735842881 cites W2001206191 @default.
• W1735842881 cites W2005518727 @default.
• W1735842881 cites W2007440573 @default.
• W1735842881 cites W2007937019 @default.
• W1735842881 cites W2015566312 @default.
• W1735842881 cites W2019945571 @default.
• W1735842881 cites W2021081821 @default.
• W1735842881 cites W2023794063 @default.
• W1735842881 cites W2024202109 @default.
• W1735842881 cites W2024960351 @default.
• W1735842881 cites W2025136926 @default.
• W1735842881 cites W2027666635 @default.
• W1735842881 cites W2029837012 @default.
• W1735842881 cites W2030275699 @default.
• W1735842881 cites W2042899073 @default.
• W1735842881 cites W2052234559 @default.
• W1735842881 cites W2056013076 @default.
• W1735842881 cites W2058321869 @default.
• W1735842881 cites W2062648442 @default.
• W1735842881 cites W2064642280 @default.
• W1735842881 cites W2065284764 @default.
• W1735842881 cites W2074193626 @default.
• W1735842881 cites W2074696097 @default.
• W1735842881 cites W2077358733 @default.
• W1735842881 cites W2080279472 @default.
• W1735842881 cites W2089772634 @default.
• W1735842881 cites W2094246054 @default.
• W1735842881 cites W2095002839 @default.
• W1735842881 cites W2104039064 @default.
• W1735842881 cites W2104790962 @default.
• W1735842881 cites W2109592556 @default.
• W1735842881 cites W2119363252 @default.
• W1735842881 cites W2128501867 @default.
• W1735842881 cites W2134579473 @default.
• W1735842881 cites W2141041110 @default.
• W1735842881 cites W2144850057 @default.
• W1735842881 cites W2150178198 @default.
• W1735842881 cites W2163792649 @default.
• W1735842881 cites W2185782716 @default.
• W1735842881 cites W2248558896 @default.
• W1735842881 cites W2326189411 @default.
• W1735842881 cites W2344345396 @default.
• W1735842881 cites W2505630186 @default.
• W1735842881 cites W426892264 @default.
• W1735842881 cites W49145843 @default.
• W1735842881 cites W1581714400 @default.
• W1735842881 doi "https://doi.org/10.1111/j.1476-5381.2011.01413.x" @default.
• W1735842881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3246711" @default.
• W1735842881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21486273" @default.
• W1735842881 hasPublicationYear "2011" @default.
• W1735842881 type Work @default.
• W1735842881 sameAs 1735842881 @default.
• W1735842881 citedByCount "36" @default.
• W1735842881 countsByYear W17358428812012 @default.
• W1735842881 countsByYear W17358428812013 @default.
• W1735842881 countsByYear W17358428812014 @default.
• W1735842881 countsByYear W17358428812015 @default.
• W1735842881 countsByYear W17358428812016 @default.
• W1735842881 countsByYear W17358428812017 @default.
• W1735842881 countsByYear W17358428812018 @default.
• W1735842881 countsByYear W17358428812019 @default.
• W1735842881 countsByYear W17358428812020 @default.
• W1735842881 countsByYear W17358428812021 @default.
• W1735842881 countsByYear W17358428812022 @default.
• W1735842881 countsByYear W17358428812023 @default.
• W1735842881 crossrefType "journal-article" @default.
• W1735842881 hasAuthorship W1735842881A5007936747 @default.
• W1735842881 hasAuthorship W1735842881A5008581557 @default.
• W1735842881 hasAuthorship W1735842881A5023851695 @default.
• W1735842881 hasAuthorship W1735842881A5062798808 @default.
• W1735842881 hasAuthorship W1735842881A5066801642 @default.
• W1735842881 hasAuthorship W1735842881A5089371574 @default.
• W1735842881 hasBestOaLocation W17358428811 @default.
• W1735842881 hasConcept C10146269 @default.
• W1735842881 hasConcept C112705442 @default.
• W1735842881 hasConcept C121332964 @default.
• W1735842881 hasConcept C125287762 @default.

• next