FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1736016875> ?p ?o ?g. }

• W1736016875 endingPage "196" @default.
• W1736016875 startingPage "186" @default.
• W1736016875 abstract "Aim SRT 2104 is a novel, first‐in‐class, highly selective small molecule activator of the NAD + dependent deacetylase SIRT 1. SRT 2104 was dosed to healthy male and female volunteers in a series of phase 1 clinical studies that were designed to elucidate tolerability and pharmacokinetics associated with oral dosing to aid in dose selection for subsequent clinical trials. Methods In the first‐in‐human study, there was both a single dose phase and 7 day repeat dose phase. Doses used ranged from 0.03 to 3.0 g. A radioactive microtracer study was subsequently conducted to determine systemic clearance, bioavailability and preliminary metabolism, and a crossover study was conducted to determine the effect of gender, formulation and feeding state on SRT 2104 pharmacokinetics. Results SRT 2104 was well tolerated in all of these studies, with no serious adverse reactions observed. SRT 2104 displayed a dose‐dependent, but sub‐proportional increase in exposure following single dose and repeated dose administration. Accumulation of three‐fold or less occurs after 7 days of repeat dosing. The mean bioavailability was circa 14% and the mean clearance was circa 400 ml min −1 . Although there were no substantial effects on exposure resulting from gender or formulation differences, a notable food effect was observed, manifested as up to four‐fold increase in exposure parameters. Conclusions In the absence of an optimized formulation of SRT 2104, the food effect can be used to maximize exposure in future clinical studies. Combined with the good tolerability of all doses demonstrated in these studies, the favourable selectivity profile of SRT 2104 allows for the use of this SIRT 1 modulator for target validation in the clinic." @default.
• W1736016875 created "2016-06-24" @default.
• W1736016875 creator A5001520736 @default.
• W1736016875 creator A5006879666 @default.
• W1736016875 creator A5011185510 @default.
• W1736016875 creator A5038290045 @default.
• W1736016875 creator A5039753808 @default.
• W1736016875 creator A5049969887 @default.
• W1736016875 creator A5077757894 @default.
• W1736016875 creator A5080450234 @default.
• W1736016875 creator A5090337636 @default.
• W1736016875 date "2012-12-14" @default.
• W1736016875 modified "2023-10-17" @default.
• W1736016875 title "Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man" @default.
• W1736016875 cites W1932895848 @default.
• W1736016875 cites W1969408132 @default.
• W1736016875 cites W1970578757 @default.
• W1736016875 cites W1983465246 @default.
• W1736016875 cites W1988733714 @default.
• W1736016875 cites W1992635584 @default.
• W1736016875 cites W2005789183 @default.
• W1736016875 cites W2009826707 @default.
• W1736016875 cites W2029997359 @default.
• W1736016875 cites W2031213396 @default.
• W1736016875 cites W2033048925 @default.
• W1736016875 cites W2034451927 @default.
• W1736016875 cites W2034896461 @default.
• W1736016875 cites W2041959419 @default.
• W1736016875 cites W2055539528 @default.
• W1736016875 cites W2058272015 @default.
• W1736016875 cites W2074740541 @default.
• W1736016875 cites W2075747312 @default.
• W1736016875 cites W2077834313 @default.
• W1736016875 cites W2080192652 @default.
• W1736016875 cites W2083215899 @default.
• W1736016875 cites W2087406283 @default.
• W1736016875 cites W2088381487 @default.
• W1736016875 cites W2091457094 @default.
• W1736016875 cites W2091685314 @default.
• W1736016875 cites W2096882254 @default.
• W1736016875 cites W2097042870 @default.
• W1736016875 cites W2100978260 @default.
• W1736016875 cites W2102042071 @default.
• W1736016875 cites W2106715610 @default.
• W1736016875 cites W2110271190 @default.
• W1736016875 cites W2112219505 @default.
• W1736016875 cites W2116350182 @default.
• W1736016875 cites W2120694386 @default.
• W1736016875 cites W2124541044 @default.
• W1736016875 cites W2124595934 @default.
• W1736016875 cites W2124898423 @default.
• W1736016875 cites W2128737073 @default.
• W1736016875 cites W2131707839 @default.
• W1736016875 cites W2135711139 @default.
• W1736016875 cites W2136830554 @default.
• W1736016875 cites W2138134399 @default.
• W1736016875 cites W2140925956 @default.
• W1736016875 cites W2143499920 @default.
• W1736016875 cites W2144600435 @default.
• W1736016875 cites W2152101492 @default.
• W1736016875 cites W2153975084 @default.
• W1736016875 cites W2155590575 @default.
• W1736016875 cites W2158124286 @default.
• W1736016875 cites W2158153532 @default.
• W1736016875 cites W2162002052 @default.
• W1736016875 cites W2162306102 @default.
• W1736016875 cites W2165722123 @default.
• W1736016875 cites W2169695019 @default.
• W1736016875 doi "https://doi.org/10.1111/j.1365-2125.2012.04340.x" @default.
• W1736016875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3555058" @default.
• W1736016875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22616762" @default.
• W1736016875 hasPublicationYear "2012" @default.
• W1736016875 type Work @default.
• W1736016875 sameAs 1736016875 @default.
• W1736016875 citedByCount "109" @default.
• W1736016875 countsByYear W17360168752012 @default.
• W1736016875 countsByYear W17360168752013 @default.
• W1736016875 countsByYear W17360168752014 @default.
• W1736016875 countsByYear W17360168752015 @default.
• W1736016875 countsByYear W17360168752016 @default.
• W1736016875 countsByYear W17360168752017 @default.
• W1736016875 countsByYear W17360168752018 @default.
• W1736016875 countsByYear W17360168752019 @default.
• W1736016875 countsByYear W17360168752020 @default.
• W1736016875 countsByYear W17360168752021 @default.
• W1736016875 countsByYear W17360168752022 @default.
• W1736016875 countsByYear W17360168752023 @default.
• W1736016875 crossrefType "journal-article" @default.
• W1736016875 hasAuthorship W1736016875A5001520736 @default.
• W1736016875 hasAuthorship W1736016875A5006879666 @default.
• W1736016875 hasAuthorship W1736016875A5011185510 @default.
• W1736016875 hasAuthorship W1736016875A5038290045 @default.
• W1736016875 hasAuthorship W1736016875A5039753808 @default.
• W1736016875 hasAuthorship W1736016875A5049969887 @default.
• W1736016875 hasAuthorship W1736016875A5077757894 @default.
• W1736016875 hasAuthorship W1736016875A5080450234 @default.
• W1736016875 hasAuthorship W1736016875A5090337636 @default.
• W1736016875 hasBestOaLocation W17360168752 @default.

• next