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• W173611128 abstract "Research Article1 March 1989free access N-myc transgene promotes B lymphoid proliferation, elicits lymphomas and reveals cross-regulation with c-myc. H. Rosenbaum H. Rosenbaum Waller and Eliza Hall Institute of Medical Research, Melbourne Hospital, Australia. Search for more papers by this author E. Webb E. Webb Waller and Eliza Hall Institute of Medical Research, Melbourne Hospital, Australia. Search for more papers by this author J. M. Adams J. M. Adams Waller and Eliza Hall Institute of Medical Research, Melbourne Hospital, Australia. Search for more papers by this author S. Cory S. Cory Waller and Eliza Hall Institute of Medical Research, Melbourne Hospital, Australia. Search for more papers by this author A. W. Harris A. W. Harris Waller and Eliza Hall Institute of Medical Research, Melbourne Hospital, Australia. Search for more papers by this author H. Rosenbaum H. Rosenbaum Waller and Eliza Hall Institute of Medical Research, Melbourne Hospital, Australia. Search for more papers by this author E. Webb E. Webb Waller and Eliza Hall Institute of Medical Research, Melbourne Hospital, Australia. Search for more papers by this author J. M. Adams J. M. Adams Waller and Eliza Hall Institute of Medical Research, Melbourne Hospital, Australia. Search for more papers by this author S. Cory S. Cory Waller and Eliza Hall Institute of Medical Research, Melbourne Hospital, Australia. Search for more papers by this author A. W. Harris A. W. Harris Waller and Eliza Hall Institute of Medical Research, Melbourne Hospital, Australia. Search for more papers by this author Author Information H. Rosenbaum1, E. Webb1, J. M. Adams1, S. Cory1 and A. W. Harris1 1Waller and Eliza Hall Institute of Medical Research, Melbourne Hospital, Australia. The EMBO Journal (1989)8:749-755https://doi.org/10.1002/j.1460-2075.1989.tb03435.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info To assess the impact of constitutive N-myc expression on lymphocytes, we generated lines of transgenic mice bearing the murine N-myc oncogene coupled to the immunoglobulin heavy chain enhancer (E mu). As in mice carrying an analogous c-myc construct, E mu-N-myc mice exhibit a limited overgrowth of cycling pre-B cells and eventually succumb to clonal B lymphoid tumours. The endogenous N-myc and c-myc alleles are silent in both E mu-N-myc and E mu-myc lymphomas, suggesting that these genes are subject to auto- and cross-regulation. The regulatory interaction and the similar biological effects of N-myc and c-myc imply that the two genes perform interchangeable functions in the promotion of cell proliferation. Previous ArticleNext Article Volume 8Issue 31 March 1989In this issue RelatedDetailsLoading ..." @default.
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• W173611128 title "N-myc transgene promotes B lymphoid proliferation, elicits lymphomas and reveals cross-regulation with c-myc." @default.
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