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- W173621709 abstract "The rhizome of Zingiber officinale Roscoe [family: Zingiberaceae], commonly known as ‘ginger’, is one of the regularly used spices in many parts of the world. In addition to its dietary use, ginger has a long history of medicinal use in the various traditional and folk system of medicine to treat various gastrointestinal ailments, asthma, heart conditions, respiratory disorders, many inflammatory conditions and associated pain and rheumatic complaints. The observed myriad beneficial effects are supposed to be due to the presence of bioactive phytochemicals like gingerols, shogaols, paradols, gingerdiols, and zingerone. Studies carried out during the past two decades have validated many of the ethnomedicinal observations and also increased the attention among scientists and researchers to attempt deciphering the reasons for these health benefits. In the present review, for the first time we summarize the findings from some of the most significant preclinical and clinical studies with ginger and some of its phytochemicals in arthritic diseases. The review also addresses the mechanism of actions responsible for the observed effects especially the free radical scavenging, antioxidant, anti-inflammatory, inhibition of nitric oxide, modulation of cytokines, decreasing the activity of metalloproteinase and decreasing activation of NF-ĸb. The review also addresses the lacunae in our knowledge and the possible reasons for the contradictory observations in the limited human trial studies." @default.
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- W173621709 date "2013-01-01" @default.
- W173621709 modified "2023-09-28" @default.
- W173621709 title "Ginger (Zingiber officinale Roscoe) in the Treatment and Prevention of Arthritis" @default.
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- W173621709 doi "https://doi.org/10.1016/b978-0-12-397156-2.00199-x" @default.
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