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- W173645315 abstract "The kidney has two populations of nephrons, cortical CN and juxtamedullary JMN. CN are the majority 85%, show autoregulation and have short loops of Henle; JMN have long loops of Henle. Disorders such as essential hypertension EHT and drugs are thought to have different effects on CN and JMN. A stochastic approach with a linear system model has been developed using I-123 orthoiodohippurate IOIH (2mCi) which tracer is taken up and proximally tubularly secreted by both CN and JNN in proportion to flow. In 12 normal volunteers Indoramin increased flow to CN by 17% whereas in 6 others Ibopamine reduced CN flow by 19% (p<0.05) but tended to increase JMN flow causing a water diuresis. The study shows that the two populations of nephrons should be considered separately in the pathophysiology and pharmacology of renal disorders." @default.
- W173645315 created "2016-06-24" @default.
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- W173645315 date "1985-05-01" @default.
- W173645315 modified "2023-09-24" @default.
- W173645315 title "Intrarenal plasma flow measurement noninvasively in man with 123-I orthoiodohippurate" @default.
- W173645315 hasPublicationYear "1985" @default.
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