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- W1736532950 abstract "Chemokine receptors and their counterpart ligands are one of the evolutionary innovations of vertebrates. They play a guiding role in the coordination of cell trafficking in many biological processes. Comparative syntenic and phylogenetic analyses provide insight into the evolution of chemokine receptors and suggest that the repertoire of chemokine receptors varies in each species, regardless of the evolutionary position of the species. Despite the rapid evolution of chemokine receptors, the expression and function of orthologous chemokine receptors in lower and higher vertebrates are very similar. This is also true for the chemokine ligands that have been examined so far, such as CXCL 8, CXCL 12, and CCL 25. As examples, this review will discuss how the evolution of the chemokine receptor CXCR 4 is coincident with the emergence of lymphocytes in jawless vertebrates (lamprey); and that, in jawed vertebrates, CXCR 4 and CCR 9 are involved in thymus colonization. In myeloid cells, the function of CXCR 1 in neutrophils and the expression of CXCR 3 in macrophages and DC s are evolutionarily conserved between fish and mammals. In this context, medaka and zebrafish are outstanding models for studying the function of chemokines and their receptors." @default.
- W1736532950 created "2016-06-24" @default.
- W1736532950 creator A5090584471 @default.
- W1736532950 date "2013-07-01" @default.
- W1736532950 modified "2023-10-17" @default.
- W1736532950 title "Evolution and function of chemokine receptors in the immune system of lower vertebrates" @default.
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- W1736532950 doi "https://doi.org/10.1002/eji.201343557" @default.
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