Matches in SemOpenAlex for { <https://semopenalex.org/work/W17366809> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W17366809 endingPage "102" @default.
- W17366809 startingPage "93" @default.
- W17366809 abstract "AbstractThe quantification of drug interaction with NMDA receptors has been greatly facilitated by the use of ligand binding assays. The first assays for this receptor measured NMDA-sensitive [3H]glutamate binding (see 1 for review). However, [3H]glutamate has relatively low affinity for the receptor, and is also a substrate for transport processes in brain membranes, which can make it difficult to isolate receptor binding from ligand sequestration. The recognition that dissociative anesthetics, such as phencyclidine and ketamine, were NMDA receptor antagonists (2,3) was an important pharmacological advance, because these drugs were more potent NMDA antagonists that others available at the time. However, phencyclidine also proved to be a difficult ligand to use because of nonspecific binding. The identification of MK801 (dizocilpine) and thienylphencyclidine (TCP) as highly potent and very selective inhibitors of NMDA receptor function (4–6) brought the possibility of ligand binding to NMDA receptors into the mainstream.KeywordsNMDA ReceptorLigand Binding AssayGlycine SiteNMDA Receptor FunctionFilter StripThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W17366809 created "2016-06-24" @default.
- W17366809 creator A5024772047 @default.
- W17366809 creator A5067675806 @default.
- W17366809 date "2003-11-14" @default.
- W17366809 modified "2023-09-29" @default.
- W17366809 title "The Use of Ligand Binding in Assays of NMDA Receptor Function" @default.
- W17366809 cites W1600539804 @default.
- W17366809 cites W1772604871 @default.
- W17366809 cites W1839333079 @default.
- W17366809 cites W1845239075 @default.
- W17366809 cites W1975514155 @default.
- W17366809 cites W1978397548 @default.
- W17366809 cites W1980378724 @default.
- W17366809 cites W1995056605 @default.
- W17366809 cites W2004273976 @default.
- W17366809 cites W2012296805 @default.
- W17366809 cites W2026389045 @default.
- W17366809 cites W2027225420 @default.
- W17366809 cites W2036209909 @default.
- W17366809 cites W2039872800 @default.
- W17366809 cites W2048152070 @default.
- W17366809 cites W2054341971 @default.
- W17366809 cites W2070039760 @default.
- W17366809 cites W2081678712 @default.
- W17366809 cites W2170029299 @default.
- W17366809 cites W2395340796 @default.
- W17366809 cites W2417803326 @default.
- W17366809 doi "https://doi.org/10.1385/1-59259-683-5:93" @default.
- W17366809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10320975" @default.
- W17366809 hasPublicationYear "2003" @default.
- W17366809 type Work @default.
- W17366809 sameAs 17366809 @default.
- W17366809 citedByCount "4" @default.
- W17366809 countsByYear W173668092017 @default.
- W17366809 crossrefType "book-chapter" @default.
- W17366809 hasAuthorship W17366809A5024772047 @default.
- W17366809 hasAuthorship W17366809A5067675806 @default.
- W17366809 hasConcept C107824862 @default.
- W17366809 hasConcept C116569031 @default.
- W17366809 hasConcept C160268369 @default.
- W17366809 hasConcept C169760540 @default.
- W17366809 hasConcept C170493617 @default.
- W17366809 hasConcept C185592680 @default.
- W17366809 hasConcept C2777836312 @default.
- W17366809 hasConcept C2778851735 @default.
- W17366809 hasConcept C55493867 @default.
- W17366809 hasConcept C67018056 @default.
- W17366809 hasConcept C86803240 @default.
- W17366809 hasConcept C98274493 @default.
- W17366809 hasConceptScore W17366809C107824862 @default.
- W17366809 hasConceptScore W17366809C116569031 @default.
- W17366809 hasConceptScore W17366809C160268369 @default.
- W17366809 hasConceptScore W17366809C169760540 @default.
- W17366809 hasConceptScore W17366809C170493617 @default.
- W17366809 hasConceptScore W17366809C185592680 @default.
- W17366809 hasConceptScore W17366809C2777836312 @default.
- W17366809 hasConceptScore W17366809C2778851735 @default.
- W17366809 hasConceptScore W17366809C55493867 @default.
- W17366809 hasConceptScore W17366809C67018056 @default.
- W17366809 hasConceptScore W17366809C86803240 @default.
- W17366809 hasConceptScore W17366809C98274493 @default.
- W17366809 hasLocation W173668091 @default.
- W17366809 hasLocation W173668092 @default.
- W17366809 hasOpenAccess W17366809 @default.
- W17366809 hasPrimaryLocation W173668091 @default.
- W17366809 hasRelatedWork W1969133295 @default.
- W17366809 hasRelatedWork W1969161817 @default.
- W17366809 hasRelatedWork W1999197073 @default.
- W17366809 hasRelatedWork W1999315981 @default.
- W17366809 hasRelatedWork W2007023757 @default.
- W17366809 hasRelatedWork W2032739515 @default.
- W17366809 hasRelatedWork W2094751803 @default.
- W17366809 hasRelatedWork W2127328539 @default.
- W17366809 hasRelatedWork W2754104338 @default.
- W17366809 hasRelatedWork W2776651958 @default.
- W17366809 isParatext "false" @default.
- W17366809 isRetracted "false" @default.
- W17366809 magId "17366809" @default.
- W17366809 workType "book-chapter" @default.