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• W173668228 abstract "Oncology remains a major focus of the pharmaceutical industry, and they are investing heavily in the forward effort to move drugs and biologics through development to regulatory approval. The discovery and early preclinical development throughput for safety, tumor cell binding, and in vivo biodistribution are hindered by the complications and the uniqueness of frequently contrived xenobiotic animal models, generally in murine strains. Animal numbers for adequate sensitivity, tumor heterogeneity of response, and metabolism make for high tumor-to-tumor variance in growth and response. The throughput of studies (tumor growth periods), powering studies sufficiently for decisional steps in product advancement, and the general “how do we do the human translation” all contribute to the major costs in this arm of the pharmaceutical business. Imaging offers many advantages to help solve, or at least allay, these issues. Imaging can pinpoint the tumor uptake heterogeneity, it can reduce the numbers of animals as quantitative assessments can be done on fewer animals, it allows for each animal to serve as its own control, and it allows multiple time point sampling in the same animal(s) during the tumor gestation, eruption, and time window for optimal therapeutic intervention. This chapter will hopefully guide the reader through multiple examples of how to investigate tumor biology using imaging in the nonclinical environment and hopefully will provide useful approaches and ideas for inclusion in their oncology programs." @default.
• W173668228 created "2016-06-24" @default.
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• W173668228 date "2013-09-21" @default.
• W173668228 modified "2023-09-27" @default.
• W173668228 title "Preclinical Imaging in Oncology: Considerations and Recommendations for the Imaging Scientist" @default.
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• W173668228 doi "https://doi.org/10.1007/978-1-4614-8247-5_7" @default.
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