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- W1736683502 abstract "Abstract Objectives The protective effects of estrogen replacement therapy (ERT) against oxidative injury and endothelial dysfunction in the aortic tissues induced with nicotine in ovariectomized (OVX) rats were investigated. Methods Female rats were divided into a sham-operated group (n = 8) and four groups in which OVX rats received either vehicle (0.1 ml sesame oil, i.m., n = 8), or nicotine (0.1 mg/kg, s.c., n = 8), or estradiol benzoate (0.1 mg/kg, i.m., n = 8), or both nicotine and estradiol benzoate (n = 8) starting at week 5 after the surgery and continuing for the following 6 weeks. Key findings ERT was effective in preventing the rise in plasma lipid profile, atherogenic index and the level of induced endothelin-1 (ET-1) in nicotine-treated OVX rats. It also reduced aortic malondialdehyde, hydroxyproline levels, calcium content and caspase-3 expression induced in nicotine-treated OVX rats. ERT increased serum estradiol, high-density lipoprotein cholesterol and nitric oxide levels in nicotine-treated OVX rats. Furthermore, ERT was effective in restoring reduced glutathione and cyclic guanosine monophosphate contents and endothelial nitric oxide synthase expression in aortic tissues of nicotine-treated OVX rats. Conclusions Short-term ERT could be a promising therapeutic strategy to minimize nicotine-induced oxidative stress and vascular endothelial dysfunction in menopausal women subjected to environmental smoke." @default.
- W1736683502 created "2016-06-24" @default.
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- W1736683502 date "2011-11-04" @default.
- W1736683502 modified "2023-09-27" @default.
- W1736683502 title "Nicotine and vascular endothelial dysfunction in female ovariectomized rats: role of estrogen replacement therapy" @default.
- W1736683502 cites W1511296430 @default.
- W1736683502 cites W1521496056 @default.
- W1736683502 cites W1590457525 @default.
- W1736683502 cites W1895532472 @default.
- W1736683502 cites W1966192074 @default.
- W1736683502 cites W1969098462 @default.
- W1736683502 cites W1970499787 @default.
- W1736683502 cites W1971629767 @default.
- W1736683502 cites W1972590797 @default.
- W1736683502 cites W1973484570 @default.
- W1736683502 cites W1979052200 @default.
- W1736683502 cites W1981523425 @default.
- W1736683502 cites W1986979630 @default.
- W1736683502 cites W1988641424 @default.
- W1736683502 cites W1989240710 @default.
- W1736683502 cites W1990857099 @default.
- W1736683502 cites W1991323891 @default.
- W1736683502 cites W2003995353 @default.
- W1736683502 cites W2004152780 @default.
- W1736683502 cites W2010481710 @default.
- W1736683502 cites W2012633834 @default.
- W1736683502 cites W2014329996 @default.
- W1736683502 cites W2018334542 @default.
- W1736683502 cites W2019008550 @default.
- W1736683502 cites W2030318393 @default.
- W1736683502 cites W2031137884 @default.
- W1736683502 cites W2037069690 @default.
- W1736683502 cites W2039080409 @default.
- W1736683502 cites W2040536651 @default.
- W1736683502 cites W2040837467 @default.
- W1736683502 cites W2041363234 @default.
- W1736683502 cites W2041462833 @default.
- W1736683502 cites W2044366653 @default.
- W1736683502 cites W2048876471 @default.
- W1736683502 cites W2069280321 @default.
- W1736683502 cites W2069629971 @default.
- W1736683502 cites W2070129113 @default.
- W1736683502 cites W2078517343 @default.
- W1736683502 cites W2078606371 @default.
- W1736683502 cites W2088127593 @default.
- W1736683502 cites W2090726752 @default.
- W1736683502 cites W2092398617 @default.
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- W1736683502 cites W2114624493 @default.
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- W1736683502 cites W2161987170 @default.
- W1736683502 cites W2163969447 @default.
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- W1736683502 doi "https://doi.org/10.1111/j.2042-7158.2011.01377.x" @default.
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