FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1736687470> ?p ?o ?g. }

• W1736687470 endingPage "824" @default.
• W1736687470 startingPage "812" @default.
• W1736687470 abstract "We have studied several novel effects of vitamin B12 (cyanocobalamin) on cellular Ca(2+) homeostasis in rat thymocytes. We determined the effect of various concentrations of vitamin B12 on intracellular Ca(2+) concentration ([Ca(2+)]i) and parameters of Ca(2+)in signaling using the fluorescent dye Fura-2. The basal [Ca(2+)]i in Ca(2+)-containing media was 115 +/- 5 nM but in vitamin B12 (10 nM)-treated thymocytes [Ca(2+)]i was decreased to 60 +/- 15 nM (mean +/- SEM) during the first 5 min. The decline in [Ca(2+)]i was accompanied by an increase in the endoplasmic reticulum Ca(2+) store, presumably as a result of Ca-ATPase activation. At the same time 100 nM-10 mM B12 induced the accumulation of Ca(2+) in mitochondria. Somewhat higher concentrations of B12 (1-10 microM) had no effect on [Ca(2+)]i. A further increase in B12 concentration with range from 50 microM to 1 mM caused a dose-dependent elevation of [Ca(2+)]i from the basal level (115 +/- 5 nM) up to 200 +/- 50 nM in thymocytes, and this elevation was partially blocked in Ca(2+)-free media. This high concentration of vitamin B12 caused a gradual decrease of endoplasmic reticulum Ca(2+) stores by means of Ca-ATPase inhibition. The B12-induced increase in [Ca(2+)]i was not observed after depletion of intracellular Ca(2+) stores, induced by addition of 2',5'-di(tert-butyl)-1,4-benzohydroquinone (BHQ), an inhibitor of endoplasmic reticulum Ca (2+)-ATPase, concanavalin A, or arachidonic acid. These studies show that vitamin B12 regulates [Ca(2+)]i via several different mechanisms at different B12 concentrations. Participation of G proteins and calmodulin activity in B12-mediated [Ca(2+)]i increase is discussed." @default.
• W1736687470 created "2016-06-24" @default.
• W1736687470 creator A5051279898 @default.
• W1736687470 creator A5055353781 @default.
• W1736687470 creator A5056967574 @default.
• W1736687470 creator A5074232978 @default.
• W1736687470 creator A5089508104 @default.
• W1736687470 date "2001-09-01" @default.
• W1736687470 modified "2023-09-27" @default.
• W1736687470 title "Modulation of Intracellular Ca2+ Concentration by Vitamin B12 in Rat Thymocytes" @default.
• W1736687470 cites W14547008 @default.
• W1736687470 cites W1497010214 @default.
• W1736687470 cites W1574360317 @default.
• W1736687470 cites W1588337995 @default.
• W1736687470 cites W1602615004 @default.
• W1736687470 cites W1643169027 @default.
• W1736687470 cites W1868276939 @default.
• W1736687470 cites W1920479129 @default.
• W1736687470 cites W1964826110 @default.
• W1736687470 cites W1982365665 @default.
• W1736687470 cites W1985732011 @default.
• W1736687470 cites W1996907401 @default.
• W1736687470 cites W1998606603 @default.
• W1736687470 cites W2008757391 @default.
• W1736687470 cites W2014922979 @default.
• W1736687470 cites W2015000880 @default.
• W1736687470 cites W2018612932 @default.
• W1736687470 cites W2022752291 @default.
• W1736687470 cites W2023272768 @default.
• W1736687470 cites W2030553906 @default.
• W1736687470 cites W2034407702 @default.
• W1736687470 cites W2036185960 @default.
• W1736687470 cites W2041690080 @default.
• W1736687470 cites W2047102829 @default.
• W1736687470 cites W2047894796 @default.
• W1736687470 cites W2055246006 @default.
• W1736687470 cites W2057327025 @default.
• W1736687470 cites W2063738193 @default.
• W1736687470 cites W2078566549 @default.
• W1736687470 cites W2085772402 @default.
• W1736687470 cites W2087806397 @default.
• W1736687470 cites W2089132475 @default.
• W1736687470 cites W2113943014 @default.
• W1736687470 cites W2123797674 @default.
• W1736687470 cites W2141260882 @default.
• W1736687470 cites W2165773311 @default.
• W1736687470 cites W2176601453 @default.
• W1736687470 cites W2329371131 @default.
• W1736687470 cites W2336320889 @default.
• W1736687470 cites W2395822803 @default.
• W1736687470 cites W2413405577 @default.
• W1736687470 cites W2418958163 @default.
• W1736687470 cites W95896594 @default.
• W1736687470 cites W2017273860 @default.
• W1736687470 doi "https://doi.org/10.1006/bcmd.2001.0450" @default.
• W1736687470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11783944" @default.
• W1736687470 hasPublicationYear "2001" @default.
• W1736687470 type Work @default.
• W1736687470 sameAs 1736687470 @default.
• W1736687470 citedByCount "6" @default.
• W1736687470 countsByYear W17366874702013 @default.
• W1736687470 countsByYear W17366874702018 @default.
• W1736687470 countsByYear W17366874702019 @default.
• W1736687470 countsByYear W17366874702022 @default.
• W1736687470 crossrefType "journal-article" @default.
• W1736687470 hasAuthorship W1736687470A5051279898 @default.
• W1736687470 hasAuthorship W1736687470A5055353781 @default.
• W1736687470 hasAuthorship W1736687470A5056967574 @default.
• W1736687470 hasAuthorship W1736687470A5074232978 @default.
• W1736687470 hasAuthorship W1736687470A5089508104 @default.
• W1736687470 hasConcept C126322002 @default.
• W1736687470 hasConcept C134018914 @default.
• W1736687470 hasConcept C158617107 @default.
• W1736687470 hasConcept C181199279 @default.
• W1736687470 hasConcept C185592680 @default.
• W1736687470 hasConcept C19869320 @default.
• W1736687470 hasConcept C202751555 @default.
• W1736687470 hasConcept C23265538 @default.
• W1736687470 hasConcept C2776989580 @default.
• W1736687470 hasConcept C2778470358 @default.
• W1736687470 hasConcept C2779750884 @default.
• W1736687470 hasConcept C519063684 @default.
• W1736687470 hasConcept C55493867 @default.
• W1736687470 hasConcept C71924100 @default.
• W1736687470 hasConcept C79879829 @default.
• W1736687470 hasConcept C86803240 @default.
• W1736687470 hasConcept C98539663 @default.
• W1736687470 hasConceptScore W1736687470C126322002 @default.
• W1736687470 hasConceptScore W1736687470C134018914 @default.
• W1736687470 hasConceptScore W1736687470C158617107 @default.
• W1736687470 hasConceptScore W1736687470C181199279 @default.
• W1736687470 hasConceptScore W1736687470C185592680 @default.
• W1736687470 hasConceptScore W1736687470C19869320 @default.
• W1736687470 hasConceptScore W1736687470C202751555 @default.
• W1736687470 hasConceptScore W1736687470C23265538 @default.
• W1736687470 hasConceptScore W1736687470C2776989580 @default.
• W1736687470 hasConceptScore W1736687470C2778470358 @default.
• W1736687470 hasConceptScore W1736687470C2779750884 @default.

• next