Matches in SemOpenAlex for { <https://semopenalex.org/work/W1736692616> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1736692616 endingPage "752" @default.
- W1736692616 startingPage "746" @default.
- W1736692616 abstract "Prior to the United Kingdom Infantile Spasms Study (UKISS), our practice was to initiate vigabatrin for infantile spasms. However, since then we tend to use steroids as first-line agent for infantile spasms. Herein we compare seizure-free outcomes in children with infantile spasms on steroid therapy or vigabatrin therapy.This was a retrospective case study over 8 years of children with infantile spasms who were treated at our center. A positive response to therapy was defined as a two-week spasm-free interval.Of the 98 children presenting to us, 75 were included for this study. The ratio of cryptogenic to symptomatic spasms was 24:51. The response rate for steroid therapy was 61.1% and 42.5% for vigabatrin. Cessation of spasms was achieved faster in the group receiving steroids. Both groups had similar relapse rates. Steroids had significantly better response in the cryptogenic group, whereas in the symptomatic group both the medications were equally effective. Cryptogenic spasms have a better neurodevelopmental outcome. Early introduction of therapy for spasms did not predict a good neurodevelopmental outcome. Seventy-eight percent of children with spasms had seizures of other types at 12 months follow-up.At our center, steroids are now the preferred choice for initial therapy of infantile spasms. This is likely to have been a beneficial change, particularly for children with cryptogenic spasms. Spasms in 25% of the patients tend to be refractory, and the majority of patients from the cohort continue to have epilepsy with motor and cognitive disabilities." @default.
- W1736692616 created "2016-06-24" @default.
- W1736692616 creator A5009068895 @default.
- W1736692616 creator A5037112726 @default.
- W1736692616 creator A5065559991 @default.
- W1736692616 creator A5072268959 @default.
- W1736692616 creator A5075402868 @default.
- W1736692616 date "2011-02-14" @default.
- W1736692616 modified "2023-10-10" @default.
- W1736692616 title "Seizure outcome in infantile spasms-A retrospective study" @default.
- W1736692616 cites W1493834814 @default.
- W1736692616 cites W1938533019 @default.
- W1736692616 cites W1967347610 @default.
- W1736692616 cites W1967778886 @default.
- W1736692616 cites W1972120957 @default.
- W1736692616 cites W1982521237 @default.
- W1736692616 cites W2002869193 @default.
- W1736692616 cites W2033778967 @default.
- W1736692616 cites W2037122149 @default.
- W1736692616 cites W2050910356 @default.
- W1736692616 cites W2054479695 @default.
- W1736692616 cites W2058728136 @default.
- W1736692616 cites W2067982021 @default.
- W1736692616 cites W2083563713 @default.
- W1736692616 cites W2112749000 @default.
- W1736692616 cites W2112967022 @default.
- W1736692616 cites W2171386011 @default.
- W1736692616 doi "https://doi.org/10.1111/j.1528-1167.2010.02963.x" @default.
- W1736692616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21320111" @default.
- W1736692616 hasPublicationYear "2011" @default.
- W1736692616 type Work @default.
- W1736692616 sameAs 1736692616 @default.
- W1736692616 citedByCount "47" @default.
- W1736692616 countsByYear W17366926162012 @default.
- W1736692616 countsByYear W17366926162013 @default.
- W1736692616 countsByYear W17366926162014 @default.
- W1736692616 countsByYear W17366926162015 @default.
- W1736692616 countsByYear W17366926162016 @default.
- W1736692616 countsByYear W17366926162017 @default.
- W1736692616 countsByYear W17366926162018 @default.
- W1736692616 countsByYear W17366926162019 @default.
- W1736692616 countsByYear W17366926162020 @default.
- W1736692616 countsByYear W17366926162021 @default.
- W1736692616 countsByYear W17366926162022 @default.
- W1736692616 countsByYear W17366926162023 @default.
- W1736692616 crossrefType "journal-article" @default.
- W1736692616 hasAuthorship W1736692616A5009068895 @default.
- W1736692616 hasAuthorship W1736692616A5037112726 @default.
- W1736692616 hasAuthorship W1736692616A5065559991 @default.
- W1736692616 hasAuthorship W1736692616A5072268959 @default.
- W1736692616 hasAuthorship W1736692616A5075402868 @default.
- W1736692616 hasConcept C118552586 @default.
- W1736692616 hasConcept C141071460 @default.
- W1736692616 hasConcept C167135981 @default.
- W1736692616 hasConcept C187212893 @default.
- W1736692616 hasConcept C2775858608 @default.
- W1736692616 hasConcept C2778186239 @default.
- W1736692616 hasConcept C2778201146 @default.
- W1736692616 hasConcept C2779888125 @default.
- W1736692616 hasConcept C2780837902 @default.
- W1736692616 hasConcept C2910479173 @default.
- W1736692616 hasConcept C42219234 @default.
- W1736692616 hasConcept C71924100 @default.
- W1736692616 hasConceptScore W1736692616C118552586 @default.
- W1736692616 hasConceptScore W1736692616C141071460 @default.
- W1736692616 hasConceptScore W1736692616C167135981 @default.
- W1736692616 hasConceptScore W1736692616C187212893 @default.
- W1736692616 hasConceptScore W1736692616C2775858608 @default.
- W1736692616 hasConceptScore W1736692616C2778186239 @default.
- W1736692616 hasConceptScore W1736692616C2778201146 @default.
- W1736692616 hasConceptScore W1736692616C2779888125 @default.
- W1736692616 hasConceptScore W1736692616C2780837902 @default.
- W1736692616 hasConceptScore W1736692616C2910479173 @default.
- W1736692616 hasConceptScore W1736692616C42219234 @default.
- W1736692616 hasConceptScore W1736692616C71924100 @default.
- W1736692616 hasIssue "4" @default.
- W1736692616 hasLocation W17366926161 @default.
- W1736692616 hasLocation W17366926162 @default.
- W1736692616 hasOpenAccess W1736692616 @default.
- W1736692616 hasPrimaryLocation W17366926161 @default.
- W1736692616 hasRelatedWork W2011767042 @default.
- W1736692616 hasRelatedWork W2245264402 @default.
- W1736692616 hasRelatedWork W2416864280 @default.
- W1736692616 hasRelatedWork W2903779991 @default.
- W1736692616 hasRelatedWork W3020707539 @default.
- W1736692616 hasRelatedWork W3120980325 @default.
- W1736692616 hasRelatedWork W3124002180 @default.
- W1736692616 hasRelatedWork W3173130965 @default.
- W1736692616 hasRelatedWork W4205850102 @default.
- W1736692616 hasRelatedWork W4245495076 @default.
- W1736692616 hasVolume "52" @default.
- W1736692616 isParatext "false" @default.
- W1736692616 isRetracted "false" @default.
- W1736692616 magId "1736692616" @default.
- W1736692616 workType "article" @default.