FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1736794870> ?p ?o ?g. }

• W1736794870 endingPage "2522" @default.
• W1736794870 startingPage "2511" @default.
• W1736794870 abstract "Treatment-related cardiac death is the primary, noncancer cause of mortality in adult survivors of childhood malignancies. Early detection of cardiac dysfunction may identify a high-risk subset of survivors for early intervention.This study sought to determine the prevalence of cardiac dysfunction in adult survivors of childhood malignancies.Echocardiographic assessment included 3-dimensional (3D) left ventricular ejection fraction (LVEF), global longitudinal and circumferential myocardial strain, and diastolic function, graded per American Society of Echocardiography guidelines in 1,820 adult (median age 31 years; range: 18 to 65 years) survivors of childhood cancer (median time from diagnosis 23 years; range: 10 to 48 years) exposed to anthracycline chemotherapy (n = 1,050), chest-directed radiotherapy (n = 306), or both (n = 464).Only 5.8% of survivors had abnormal 3D LVEFs (<50%). However, 32.1% of survivors with normal 3D LVEFs had evidence of cardiac dysfunction by global longitudinal strain (28%), American Society of Echocardiography-graded diastolic assessment (8.7%), or both. Abnormal global longitudinal strain was associated with chest-directed radiotherapy at 1 to 19.9 Gy (rate ratio [RR]: 1.38; 95% confidence interval [CI]: 1.14 to 1.66), 20 to 29.9 Gy (RR: 1.65; 95% CI: 1.31 to 2.08), and >30 Gy (RR: 2.39; 95% CI: 1.79 to 3.18) and anthracycline dose > 300 mg/m(2) (RR: 1.72; 95% CI: 1.31 to 2.26). Survivors with metabolic syndrome were twice as likely to have abnormal global longitudinal strain (RR: 1.94; 95% CI: 1.66 to 2.28) and abnormal diastolic function (RR: 1.68; 95% CI: 1.39 to 2.03) but not abnormal 3D LVEFs (RR: 1.07; 95% CI: 0.74 to 1.53).Abnormal global longitudinal strain and diastolic function are more prevalent than reduced 3D LVEF and are associated with treatment exposure. They may identify a subset of survivors at higher risk for poor clinical cardiac outcomes who may benefit from early medical intervention." @default.
• W1736794870 created "2016-06-24" @default.
• W1736794870 creator A5001183727 @default.
• W1736794870 creator A5006774665 @default.
• W1736794870 creator A5009318195 @default.
• W1736794870 creator A5009794067 @default.
• W1736794870 creator A5012975912 @default.
• W1736794870 creator A5014881409 @default.
• W1736794870 creator A5022830903 @default.
• W1736794870 creator A5037634832 @default.
• W1736794870 creator A5051249938 @default.
• W1736794870 creator A5059262359 @default.
• W1736794870 creator A5065296378 @default.
• W1736794870 creator A5065573166 @default.
• W1736794870 creator A5074267679 @default.
• W1736794870 creator A5075687476 @default.
• W1736794870 creator A5087384700 @default.
• W1736794870 creator A5088924413 @default.
• W1736794870 creator A5089743648 @default.
• W1736794870 date "2015-06-01" @default.
• W1736794870 modified "2023-10-16" @default.
• W1736794870 title "Comprehensive Echocardiographic Detection of Treatment-Related Cardiac Dysfunction in Adult Survivors of Childhood Cancer" @default.
• W1736794870 cites W1527833619 @default.
• W1736794870 cites W1910432954 @default.
• W1736794870 cites W1968148627 @default.
• W1736794870 cites W1973388707 @default.
• W1736794870 cites W1979659450 @default.
• W1736794870 cites W1980059237 @default.
• W1736794870 cites W1983279131 @default.
• W1736794870 cites W1985054501 @default.
• W1736794870 cites W1994747147 @default.
• W1736794870 cites W2001442729 @default.
• W1736794870 cites W2003529392 @default.
• W1736794870 cites W2003741757 @default.
• W1736794870 cites W2004733118 @default.
• W1736794870 cites W2009861918 @default.
• W1736794870 cites W2011825874 @default.
• W1736794870 cites W2014432477 @default.
• W1736794870 cites W2015758016 @default.
• W1736794870 cites W2029275609 @default.
• W1736794870 cites W2033289085 @default.
• W1736794870 cites W2036850632 @default.
• W1736794870 cites W2039234480 @default.
• W1736794870 cites W2039712457 @default.
• W1736794870 cites W2066017995 @default.
• W1736794870 cites W2066617715 @default.
• W1736794870 cites W2076475209 @default.
• W1736794870 cites W2089923812 @default.
• W1736794870 cites W2101099004 @default.
• W1736794870 cites W2109626360 @default.
• W1736794870 cites W2114738305 @default.
• W1736794870 cites W2116917468 @default.
• W1736794870 cites W2118127744 @default.
• W1736794870 cites W2121411489 @default.
• W1736794870 cites W2121797481 @default.
• W1736794870 cites W2129526042 @default.
• W1736794870 cites W2133304247 @default.
• W1736794870 cites W2134838884 @default.
• W1736794870 cites W2137784332 @default.
• W1736794870 cites W2144410376 @default.
• W1736794870 cites W2150062753 @default.
• W1736794870 cites W2153281463 @default.
• W1736794870 cites W2154066911 @default.
• W1736794870 cites W2154505306 @default.
• W1736794870 cites W2161776889 @default.
• W1736794870 cites W2162039240 @default.
• W1736794870 cites W2164969738 @default.
• W1736794870 cites W2607031541 @default.
• W1736794870 cites W2899848815 @default.
• W1736794870 cites W3022179669 @default.
• W1736794870 cites W36650246 @default.
• W1736794870 cites W4238251256 @default.
• W1736794870 cites W4238781556 @default.
• W1736794870 cites W4245666729 @default.
• W1736794870 doi "https://doi.org/10.1016/j.jacc.2015.04.013" @default.
• W1736794870 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4539123" @default.
• W1736794870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26065990" @default.
• W1736794870 hasPublicationYear "2015" @default.
• W1736794870 type Work @default.
• W1736794870 sameAs 1736794870 @default.
• W1736794870 citedByCount "223" @default.
• W1736794870 countsByYear W17367948702015 @default.
• W1736794870 countsByYear W17367948702016 @default.
• W1736794870 countsByYear W17367948702017 @default.
• W1736794870 countsByYear W17367948702018 @default.
• W1736794870 countsByYear W17367948702019 @default.
• W1736794870 countsByYear W17367948702020 @default.
• W1736794870 countsByYear W17367948702021 @default.
• W1736794870 countsByYear W17367948702022 @default.
• W1736794870 countsByYear W17367948702023 @default.
• W1736794870 crossrefType "journal-article" @default.
• W1736794870 hasAuthorship W1736794870A5001183727 @default.
• W1736794870 hasAuthorship W1736794870A5006774665 @default.
• W1736794870 hasAuthorship W1736794870A5009318195 @default.
• W1736794870 hasAuthorship W1736794870A5009794067 @default.
• W1736794870 hasAuthorship W1736794870A5012975912 @default.
• W1736794870 hasAuthorship W1736794870A5014881409 @default.
• W1736794870 hasAuthorship W1736794870A5022830903 @default.

• next