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- W1736804961 abstract "textabstractDespite development in surgical techniques, chemotherapy and radiotherapy,most malignancies of the central nervous system are still devastatingtumors with a poor prognosis. For example, median survival ofpatients with malignant gliomas (astrocytoma, oligodendroglioma ormixed rype) is roughly 12 months and only 5 % of the patients survivemore than 5 years after diagnosis. Fifty % of astrocytomas are rypedas glioblastoma multiforme, the most malignant form of glioma.Glioblastoma account for 15-23 % of all intracranial tumors and have avery poor median survival of 6 months with conventional therapy.Metastases account for 15-30 % of all intracranial neoplasm's and developin 25 to 30 % of all cancer patients. The overall median survivaltime after surgery followed by radiation therapy in solitary metastaticlesions ranges from 9 to 23 months, depending on the rype of primarycancer. The prognosis in patients with multiple metastases, however,is much worse. Lepto-meningeal metastases from solid tumorsare of increasing importance in neuro-oncology, because of the increasingfrequency and the severe neurologic disabiliry it causes. About0.8 to 8 % of patients with cancer develop leptomeningeal metastases andmedian survival in these patients after radio- and chemotherapy rangesfrom 7 to 24 weeks." @default.
- W1736804961 created "2016-06-24" @default.
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- W1736804961 date "1998-05-20" @default.
- W1736804961 modified "2023-09-27" @default.
- W1736804961 title "Suicide Gen Therapy for Malignant Central Nervous System Tumors" @default.
- W1736804961 hasPublicationYear "1998" @default.
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