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- W1736999324 endingPage "1937" @default.
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- W1736999324 abstract "Previous studies demonstrated that the rabbit beta-globin gene is transcribed from its own promoter and regulated as a herpes simplex virus (HSV) early gene following insertion into the early HSV thymidine kinase gene in the intact viral genome (J. R. Smiley, C. Smibert, and R. D. Everrett, J. Virol. 61:2368-2377, 1987). We report here that the beta-globin promoter remained under early control after insertion into the late HSV gene encoding glycoprotein C. On the basis of these findings, we concluded that the beta-globin promoter is functionally equivalent to an HSV early-control region. We found that a transduced human alpha-globin gene was also regulated as an early HSV gene, while two linked Alu elements mimicked the behavior of HSV late genes. These results demonstrate that certain aspects of HSV temporal regulation can be duplicated by cellular elements and provide strong support for the hypothesis that the regulation of HSV gene expression can occur through mechanisms that do not rely on recognition of virus-specific temporal control signals." @default.
- W1736999324 created "2016-06-24" @default.
- W1736999324 creator A5015898479 @default.
- W1736999324 creator A5047663657 @default.
- W1736999324 date "1989-05-01" @default.
- W1736999324 modified "2023-10-14" @default.
- W1736999324 title "Regulation of cellular genes transduced by herpes simplex virus" @default.
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- W1736999324 doi "https://doi.org/10.1128/jvi.63.5.1929-1937.1989" @default.
- W1736999324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/250605" @default.
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