FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1737331010> ?p ?o ?g. }

• W1737331010 abstract "OBJECTIVE: To evaluate the effects of amnestic mild cognitive impairment (aMCI) on semantic memory processing using event-related potentials (ERPs).BACKGROUND: Semantic memory deficits in MCI have been reported but the neurobiological mechanisms are less understood. We used ERPs to study electrophysiological changes underlying early deterioration in semantic memory associated with aMCI.DESIGN/METHODS: EEG was recorded during subject performance of the Semantic Object Retrieval Task, a paradigm where subjects responded to pairs of words referring to particular objects. Trials of “Retrieval” probed object memory (e.g., humps and desert) whereas “NonRetrieval” did not (e.g., humps and mirror). Using a multivariate analytical technique (STAT-PCA), we analyzed ERPs from young adults (YA, N=12; mean age: 21.7 yr), normal aging adults (NA, N=12; mean age 67.7 yr; CDR=0; MMSE=29.3), and aMCI patients (N=12; mean age: 69.6 yr; CDR=0.5; MMSE=28.6) to investigate patterns related to normal aging and disease processes.RESULTS: NA subjects had slower reaction times (RT) than YA subjects (p = .004) but comparable accuracy. AMCI patients had similar RT compared to NA but lower accuracy (p = .006). ERP data (threshold of p = .001) showed a central parietal component contingent upon condition (potentials more negative in NonRetrieval than in Retrieval) starting around 700 ms post-stimulus across all groups. An age-related frontal-parietal component (potentials more positive in NonRetrieval than in Retrieval in the front) was observed between 800 and 900 ms post-stimulus in NA compared to YA. This frontal-parietal component increased significantly in amplitude around 1000 ms post-stimulus in aMCI compared to NA.CONCLUSIONS: Individuals with aMCI showed deteriorated semantic memory performance with a different neurophysiological profile compared to YA and NA. The heightened neural activity in aMCI suggests greater effort in object memory retrieval, a potential compensatory mechanism at a pre-dementia stage in response to disease processes.Study Supported by: Berman Laboratory for Learning and Memory; Alzheimer’s Association New Investigator Grant NIRG-11-173815; RGK Foundation; NIA Grant #1-P30-AG12300-16. Disclosure: Dr. Chiang has nothing to disclose. Dr. Mudar has nothing to disclose. Dr. Eroh has nothing to disclose. Dr. Spence has nothing to disclose. Dr. Pudhiyidath has nothing to disclose. Dr. Tanner has nothing to disclose. Dr. Venza has nothing to disclose. Dr. Rackley has nothing to disclose. Dr. Martin-Cook has nothing to disclose. Dr. Womack has received research support from Allon Pharmaceuticals. Dr. Bartz has nothing to disclose. Dr. Kraut has nothing to disclose. Dr. Hart has nothing to disclose." @default.
• W1737331010 created "2016-06-24" @default.
• W1737331010 creator A5003935372 @default.
• W1737331010 creator A5003966683 @default.
• W1737331010 creator A5015785796 @default.
• W1737331010 creator A5031398889 @default.
• W1737331010 creator A5033894112 @default.
• W1737331010 creator A5046056109 @default.
• W1737331010 creator A5052957256 @default.
• W1737331010 creator A5054642380 @default.
• W1737331010 creator A5057636308 @default.
• W1737331010 creator A5058232087 @default.
• W1737331010 creator A5064866781 @default.
• W1737331010 creator A5082107467 @default.
• W1737331010 creator A5084123992 @default.
• W1737331010 date "2014-04-08" @default.
• W1737331010 modified "2023-09-27" @default.
• W1737331010 title "Accentuated Brain Responses During Semantic Object Memory Retrieval In Amnestic Mild Cognitive Impairment As Measured By Event-Related Potentials (P6.241)" @default.
• W1737331010 hasPublicationYear "2014" @default.
• W1737331010 type Work @default.
• W1737331010 sameAs 1737331010 @default.
• W1737331010 citedByCount "0" @default.
• W1737331010 crossrefType "journal-article" @default.
• W1737331010 hasAuthorship W1737331010A5003935372 @default.
• W1737331010 hasAuthorship W1737331010A5003966683 @default.
• W1737331010 hasAuthorship W1737331010A5015785796 @default.
• W1737331010 hasAuthorship W1737331010A5031398889 @default.
• W1737331010 hasAuthorship W1737331010A5033894112 @default.
• W1737331010 hasAuthorship W1737331010A5046056109 @default.
• W1737331010 hasAuthorship W1737331010A5052957256 @default.
• W1737331010 hasAuthorship W1737331010A5054642380 @default.
• W1737331010 hasAuthorship W1737331010A5057636308 @default.
• W1737331010 hasAuthorship W1737331010A5058232087 @default.
• W1737331010 hasAuthorship W1737331010A5064866781 @default.
• W1737331010 hasAuthorship W1737331010A5082107467 @default.
• W1737331010 hasAuthorship W1737331010A5084123992 @default.
• W1737331010 hasConcept C15744967 @default.
• W1737331010 hasConcept C169760540 @default.
• W1737331010 hasConcept C169900460 @default.
• W1737331010 hasConcept C180747234 @default.
• W1737331010 hasConcept C197914299 @default.
• W1737331010 hasConcept C2779918689 @default.
• W1737331010 hasConcept C2984915365 @default.
• W1737331010 hasConcept C522805319 @default.
• W1737331010 hasConcept C548259974 @default.
• W1737331010 hasConcept C67359045 @default.
• W1737331010 hasConcept C71924100 @default.
• W1737331010 hasConceptScore W1737331010C15744967 @default.
• W1737331010 hasConceptScore W1737331010C169760540 @default.
• W1737331010 hasConceptScore W1737331010C169900460 @default.
• W1737331010 hasConceptScore W1737331010C180747234 @default.
• W1737331010 hasConceptScore W1737331010C197914299 @default.
• W1737331010 hasConceptScore W1737331010C2779918689 @default.
• W1737331010 hasConceptScore W1737331010C2984915365 @default.
• W1737331010 hasConceptScore W1737331010C522805319 @default.
• W1737331010 hasConceptScore W1737331010C548259974 @default.
• W1737331010 hasConceptScore W1737331010C67359045 @default.
• W1737331010 hasConceptScore W1737331010C71924100 @default.
• W1737331010 hasOpenAccess W1737331010 @default.
• W1737331010 hasRelatedWork W1513147480 @default.
• W1737331010 hasRelatedWork W1556569466 @default.
• W1737331010 hasRelatedWork W1568913224 @default.
• W1737331010 hasRelatedWork W1575857513 @default.
• W1737331010 hasRelatedWork W1886558288 @default.
• W1737331010 hasRelatedWork W1950572277 @default.
• W1737331010 hasRelatedWork W2074936635 @default.
• W1737331010 hasRelatedWork W2074941559 @default.
• W1737331010 hasRelatedWork W2168847965 @default.
• W1737331010 hasRelatedWork W2257959156 @default.
• W1737331010 hasRelatedWork W2320322219 @default.
• W1737331010 hasRelatedWork W2328777278 @default.
• W1737331010 hasRelatedWork W2391608592 @default.
• W1737331010 hasRelatedWork W2564100065 @default.
• W1737331010 hasRelatedWork W2568425819 @default.
• W1737331010 hasRelatedWork W2792048064 @default.
• W1737331010 hasRelatedWork W2807478836 @default.
• W1737331010 hasRelatedWork W2901688693 @default.
• W1737331010 hasRelatedWork W353170534 @default.
• W1737331010 hasRelatedWork W2081164999 @default.
• W1737331010 hasVolume "82" @default.
• W1737331010 isParatext "false" @default.
• W1737331010 isRetracted "false" @default.
• W1737331010 magId "1737331010" @default.
• W1737331010 workType "article" @default.