Matches in SemOpenAlex for { <https://semopenalex.org/work/W1737405494> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1737405494 endingPage "114" @default.
- W1737405494 startingPage "109" @default.
- W1737405494 abstract "Gonochoristic species have a bipotential gonad that develops into a testis or an ovary. In species whose sex is determined by a genetic factor, the expression of a sex-determining gene is the first cue that directs the development of a bipotential gonad. Subsequent expression of downstream genes induces the gonad to develop into a testis or an ovary. The TGF-ß family member Gonadal soma-derived factor (Gsdf) is thought to be an important gene for gonadal development in teleost fish, and it is expressed at higher levels in the testis than in the ovary from early to mature stages. However, there is little functional information about the gene. In this study, we targeted the Gsdf coding region in the medaka fish Oryzias latipes using transcription activator-like effector nucleases (TALENs) and studied the phenotypes of the Gsdf mutant medaka. Although normal and heterozygous XY gonads developed into a testis, all XY gonads with a homozygous mutation in Gsdf developed into an ovary at early developmental stages. However, two-thirds of Gsdf mutant XY gonads developed into testes in the adult stages. These results demonstrate that although a gonad can develop into a complete testis in the absence of Gsdf, Gsdf function is critical for directing the bipotential gonad at early developmental stages. Therefore, Gsdf is an endogenous inducer of testicular development similar to a master sex-determining gene." @default.
- W1737405494 created "2016-06-24" @default.
- W1737405494 creator A5011474353 @default.
- W1737405494 creator A5025693177 @default.
- W1737405494 creator A5088969008 @default.
- W1737405494 date "2015-11-01" @default.
- W1737405494 modified "2023-10-16" @default.
- W1737405494 title "Mutation of Gonadal soma-derived factor induces medaka XY gonads to undergo ovarian development" @default.
- W1737405494 cites W1145599266 @default.
- W1737405494 cites W1505427547 @default.
- W1737405494 cites W1968260974 @default.
- W1737405494 cites W1995329979 @default.
- W1737405494 cites W1996689072 @default.
- W1737405494 cites W2001099074 @default.
- W1737405494 cites W2049147637 @default.
- W1737405494 cites W2060151171 @default.
- W1737405494 cites W2062608881 @default.
- W1737405494 cites W2081567070 @default.
- W1737405494 cites W2087264052 @default.
- W1737405494 cites W2096819533 @default.
- W1737405494 cites W2098452577 @default.
- W1737405494 cites W2102190537 @default.
- W1737405494 cites W2109356079 @default.
- W1737405494 cites W2145872734 @default.
- W1737405494 doi "https://doi.org/10.1016/j.bbrc.2015.09.112" @default.
- W1737405494 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26408909" @default.
- W1737405494 hasPublicationYear "2015" @default.
- W1737405494 type Work @default.
- W1737405494 sameAs 1737405494 @default.
- W1737405494 citedByCount "70" @default.
- W1737405494 countsByYear W17374054942016 @default.
- W1737405494 countsByYear W17374054942017 @default.
- W1737405494 countsByYear W17374054942018 @default.
- W1737405494 countsByYear W17374054942019 @default.
- W1737405494 countsByYear W17374054942020 @default.
- W1737405494 countsByYear W17374054942021 @default.
- W1737405494 countsByYear W17374054942022 @default.
- W1737405494 countsByYear W17374054942023 @default.
- W1737405494 crossrefType "journal-article" @default.
- W1737405494 hasAuthorship W1737405494A5011474353 @default.
- W1737405494 hasAuthorship W1737405494A5025693177 @default.
- W1737405494 hasAuthorship W1737405494A5088969008 @default.
- W1737405494 hasConcept C104317684 @default.
- W1737405494 hasConcept C134018914 @default.
- W1737405494 hasConcept C137487509 @default.
- W1737405494 hasConcept C2777289358 @default.
- W1737405494 hasConcept C2778324911 @default.
- W1737405494 hasConcept C2781471917 @default.
- W1737405494 hasConcept C54355233 @default.
- W1737405494 hasConcept C63405245 @default.
- W1737405494 hasConcept C86803240 @default.
- W1737405494 hasConceptScore W1737405494C104317684 @default.
- W1737405494 hasConceptScore W1737405494C134018914 @default.
- W1737405494 hasConceptScore W1737405494C137487509 @default.
- W1737405494 hasConceptScore W1737405494C2777289358 @default.
- W1737405494 hasConceptScore W1737405494C2778324911 @default.
- W1737405494 hasConceptScore W1737405494C2781471917 @default.
- W1737405494 hasConceptScore W1737405494C54355233 @default.
- W1737405494 hasConceptScore W1737405494C63405245 @default.
- W1737405494 hasConceptScore W1737405494C86803240 @default.
- W1737405494 hasFunder F4320334764 @default.
- W1737405494 hasIssue "1" @default.
- W1737405494 hasLocation W17374054941 @default.
- W1737405494 hasLocation W17374054942 @default.
- W1737405494 hasOpenAccess W1737405494 @default.
- W1737405494 hasPrimaryLocation W17374054941 @default.
- W1737405494 hasRelatedWork W1576518314 @default.
- W1737405494 hasRelatedWork W2091109771 @default.
- W1737405494 hasRelatedWork W2326856370 @default.
- W1737405494 hasRelatedWork W2409987279 @default.
- W1737405494 hasRelatedWork W2410283465 @default.
- W1737405494 hasRelatedWork W3114142080 @default.
- W1737405494 hasRelatedWork W3158210477 @default.
- W1737405494 hasRelatedWork W4299372406 @default.
- W1737405494 hasRelatedWork W4377041435 @default.
- W1737405494 hasRelatedWork W946566669 @default.
- W1737405494 hasVolume "467" @default.
- W1737405494 isParatext "false" @default.
- W1737405494 isRetracted "false" @default.
- W1737405494 magId "1737405494" @default.
- W1737405494 workType "article" @default.