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- W1737647440 abstract "Although the relative number of opiate addicts remains low, the issue of opiate addiction remains a national concern, primarily because of the problems posed by the transmission of the human immunodeficiency virus (HIV). Whereas in the past interest was fueled by the new understanding of the role of opiate receptors and noradrenergic systems in addiction, HIV has led to an increased emphasis in finding more effective treatments for opiate addiction and withdrawal. This article examines the role of the locus coeruleus in the pathogenesis of opiate addiction and withdrawal symptoms, and how changes in neurochemistry produce the withdrawal distress that can lead to relapse. Pharmacotherapy options for opiate withdrawal are discussed in detail, with special emphasis placed on how these treatment strategies address the neurochemical changes caused by opiate abuse." @default.
- W1737647440 created "2016-06-24" @default.
- W1737647440 creator A5068209735 @default.
- W1737647440 date "1993-03-01" @default.
- W1737647440 modified "2023-10-15" @default.
- W1737647440 title "Opiate Addiction and the Locus Coeruleus: The Clinical Utility of Clonidine, Naltrexone, Methadone, and Buprenorphine" @default.
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- W1737647440 doi "https://doi.org/10.1016/s0193-953x(18)30190-4" @default.
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