Matches in SemOpenAlex for { <https://semopenalex.org/work/W173810033> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W173810033 endingPage "71" @default.
- W173810033 startingPage "165" @default.
- W173810033 abstract "The aim of this study is to determine potential cataractogenic activity of atorvastatin the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. HMG-CoA reductase inhibitors (atorvastatin, lovastatin, simvastatin, pravastatin, fluvastatin, cerivastatin) (statins) are the most potent cholesterol and LDL-C lowering drugs. Statins differ in many aspects e.g. intensity of side-effects. It is possible that some hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) therapy is associated with cataract occurrence. The purpose of these studies was to focus on the potential cataractogenic contribution of atorvastatin. The studies were carried out on white Wistar rats. The animals were given atorvastatin (Sortis--Parke-Davis, USA) in two doses: 1.14 mg/kg mg/day, and 11.4 mg/day. Lens structure was observed in stereoscopic, dark-filed and in optic microscope, the cataract was observed in the examined preparations, specially high doses administered. We concluded that lens turned out to be reacting to atorvastatin. Drug dose corresponded to increase in the number and duration of cataract episodes (changes were more significant in the experimental groups 11.4 mg/kg). Alterations in the examined lens design may be a result of atorvastatin effect." @default.
- W173810033 created "2016-06-24" @default.
- W173810033 creator A5011110144 @default.
- W173810033 creator A5033796793 @default.
- W173810033 creator A5067604055 @default.
- W173810033 date "2002-01-01" @default.
- W173810033 modified "2023-09-23" @default.
- W173810033 title "The eye lens evaluation of the atorvastatin-treated white rat." @default.
- W173810033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12898835" @default.
- W173810033 hasPublicationYear "2002" @default.
- W173810033 type Work @default.
- W173810033 sameAs 173810033 @default.
- W173810033 citedByCount "5" @default.
- W173810033 countsByYear W1738100332012 @default.
- W173810033 countsByYear W1738100332013 @default.
- W173810033 countsByYear W1738100332014 @default.
- W173810033 countsByYear W1738100332023 @default.
- W173810033 crossrefType "journal-article" @default.
- W173810033 hasAuthorship W173810033A5011110144 @default.
- W173810033 hasAuthorship W173810033A5033796793 @default.
- W173810033 hasAuthorship W173810033A5067604055 @default.
- W173810033 hasConcept C104950815 @default.
- W173810033 hasConcept C126322002 @default.
- W173810033 hasConcept C134651460 @default.
- W173810033 hasConcept C181199279 @default.
- W173810033 hasConcept C185592680 @default.
- W173810033 hasConcept C2776329913 @default.
- W173810033 hasConcept C2777482532 @default.
- W173810033 hasConcept C2778163477 @default.
- W173810033 hasConcept C2778417548 @default.
- W173810033 hasConcept C2779415389 @default.
- W173810033 hasConcept C2779519902 @default.
- W173810033 hasConcept C2780940807 @default.
- W173810033 hasConcept C55493867 @default.
- W173810033 hasConcept C71924100 @default.
- W173810033 hasConcept C98274493 @default.
- W173810033 hasConceptScore W173810033C104950815 @default.
- W173810033 hasConceptScore W173810033C126322002 @default.
- W173810033 hasConceptScore W173810033C134651460 @default.
- W173810033 hasConceptScore W173810033C181199279 @default.
- W173810033 hasConceptScore W173810033C185592680 @default.
- W173810033 hasConceptScore W173810033C2776329913 @default.
- W173810033 hasConceptScore W173810033C2777482532 @default.
- W173810033 hasConceptScore W173810033C2778163477 @default.
- W173810033 hasConceptScore W173810033C2778417548 @default.
- W173810033 hasConceptScore W173810033C2779415389 @default.
- W173810033 hasConceptScore W173810033C2779519902 @default.
- W173810033 hasConceptScore W173810033C2780940807 @default.
- W173810033 hasConceptScore W173810033C55493867 @default.
- W173810033 hasConceptScore W173810033C71924100 @default.
- W173810033 hasConceptScore W173810033C98274493 @default.
- W173810033 hasIssue "2" @default.
- W173810033 hasLocation W1738100331 @default.
- W173810033 hasOpenAccess W173810033 @default.
- W173810033 hasPrimaryLocation W1738100331 @default.
- W173810033 hasRelatedWork W158929996 @default.
- W173810033 hasRelatedWork W1778499707 @default.
- W173810033 hasRelatedWork W1970666872 @default.
- W173810033 hasRelatedWork W2011843648 @default.
- W173810033 hasRelatedWork W2038338711 @default.
- W173810033 hasRelatedWork W2045063002 @default.
- W173810033 hasRelatedWork W2149392568 @default.
- W173810033 hasRelatedWork W2242789166 @default.
- W173810033 hasRelatedWork W2517970972 @default.
- W173810033 hasRelatedWork W2947959412 @default.
- W173810033 hasVolume "57" @default.
- W173810033 isParatext "false" @default.
- W173810033 isRetracted "false" @default.
- W173810033 magId "173810033" @default.
- W173810033 workType "article" @default.