FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1738174518> ?p ?o ?g. }

• W1738174518 endingPage "70" @default.
• W1738174518 startingPage "163" @default.
• W1738174518 abstract "Excessive breakdown of extracellular matrix by metalloproteinases (MMPs) occurs in many pathological conditions. Consequently, methods for inhibiting MMP activity have therapeutic potential. In this study, we investigated the effect of G-120, a 120 kDa glycoprotein purified from the Oriental herbal plant, Ulmus davidiana Nakai (UDN), on the activity and production of several MMPs by evaluating its growth inhibitory effect on NIH 3T3 cells. Tritium uptake assays showed that proliferation of NIH 3T3 cells was strongly suppressed, and G-120-mediated inhibition of DNA synthesis proved to involve a cytostatic, rather than a cytotoxic, effect, as shown by cytotoxicity and apoptosis assays. More importantly, G-120 strongly reduced the gelatinolytic and collagenase activities of MMP proteins, as well as expression of MMP-2 and MMP-9. Electrophoretic mobility shift assays revealed that it suppressed the DNA binding activity of NF-kappaB. Collectively, our observations show that G-120 strongly inhibits the activation of MMPs and NF-kappaB." @default.
• W1738174518 created "2016-06-24" @default.
• W1738174518 creator A5008400370 @default.
• W1738174518 creator A5030863704 @default.
• W1738174518 creator A5042831506 @default.
• W1738174518 creator A5044518854 @default.
• W1738174518 creator A5071197071 @default.
• W1738174518 creator A5075941165 @default.
• W1738174518 creator A5082638117 @default.
• W1738174518 creator A5084466098 @default.
• W1738174518 date "2004-10-31" @default.
• W1738174518 modified "2023-10-16" @default.
• W1738174518 title "Inhibitory effects of glycoprotein-120 (G-120) from Ulmus davidiana Nakai on cell growth and activation of matrix metalloproteinases." @default.
• W1738174518 cites W150455313 @default.
• W1738174518 cites W1546229037 @default.
• W1738174518 cites W177941455 @default.
• W1738174518 cites W1943170591 @default.
• W1738174518 cites W1949259756 @default.
• W1738174518 cites W1973645860 @default.
• W1738174518 cites W1980480613 @default.
• W1738174518 cites W1983187343 @default.
• W1738174518 cites W1986382066 @default.
• W1738174518 cites W1986884128 @default.
• W1738174518 cites W1993596576 @default.
• W1738174518 cites W1995912941 @default.
• W1738174518 cites W2012904032 @default.
• W1738174518 cites W2020866554 @default.
• W1738174518 cites W2034002539 @default.
• W1738174518 cites W2048099756 @default.
• W1738174518 cites W2048273482 @default.
• W1738174518 cites W2050525007 @default.
• W1738174518 cites W2051347744 @default.
• W1738174518 cites W2055758035 @default.
• W1738174518 cites W2057055923 @default.
• W1738174518 cites W2057896496 @default.
• W1738174518 cites W2065093943 @default.
• W1738174518 cites W2066315131 @default.
• W1738174518 cites W2093521383 @default.
• W1738174518 cites W2106319388 @default.
• W1738174518 cites W2128635872 @default.
• W1738174518 cites W2164471424 @default.
• W1738174518 cites W2410303910 @default.
• W1738174518 cites W753851839 @default.
• W1738174518 cites W905350287 @default.
• W1738174518 cites W981195140 @default.
• W1738174518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15528991" @default.
• W1738174518 hasPublicationYear "2004" @default.
• W1738174518 type Work @default.
• W1738174518 sameAs 1738174518 @default.
• W1738174518 citedByCount "1" @default.
• W1738174518 crossrefType "journal-article" @default.
• W1738174518 hasAuthorship W1738174518A5008400370 @default.
• W1738174518 hasAuthorship W1738174518A5030863704 @default.
• W1738174518 hasAuthorship W1738174518A5042831506 @default.
• W1738174518 hasAuthorship W1738174518A5044518854 @default.
• W1738174518 hasAuthorship W1738174518A5071197071 @default.
• W1738174518 hasAuthorship W1738174518A5075941165 @default.
• W1738174518 hasAuthorship W1738174518A5082638117 @default.
• W1738174518 hasAuthorship W1738174518A5084466098 @default.
• W1738174518 hasConcept C108625454 @default.
• W1738174518 hasConcept C109316439 @default.
• W1738174518 hasConcept C109523444 @default.
• W1738174518 hasConcept C134018914 @default.
• W1738174518 hasConcept C153911025 @default.
• W1738174518 hasConcept C154317977 @default.
• W1738174518 hasConcept C17077164 @default.
• W1738174518 hasConcept C185592680 @default.
• W1738174518 hasConcept C189165786 @default.
• W1738174518 hasConcept C190283241 @default.
• W1738174518 hasConcept C202751555 @default.
• W1738174518 hasConcept C55493867 @default.
• W1738174518 hasConcept C62112901 @default.
• W1738174518 hasConcept C86803240 @default.
• W1738174518 hasConcept C95444343 @default.
• W1738174518 hasConceptScore W1738174518C108625454 @default.
• W1738174518 hasConceptScore W1738174518C109316439 @default.
• W1738174518 hasConceptScore W1738174518C109523444 @default.
• W1738174518 hasConceptScore W1738174518C134018914 @default.
• W1738174518 hasConceptScore W1738174518C153911025 @default.
• W1738174518 hasConceptScore W1738174518C154317977 @default.
• W1738174518 hasConceptScore W1738174518C17077164 @default.
• W1738174518 hasConceptScore W1738174518C185592680 @default.
• W1738174518 hasConceptScore W1738174518C189165786 @default.
• W1738174518 hasConceptScore W1738174518C190283241 @default.
• W1738174518 hasConceptScore W1738174518C202751555 @default.
• W1738174518 hasConceptScore W1738174518C55493867 @default.
• W1738174518 hasConceptScore W1738174518C62112901 @default.
• W1738174518 hasConceptScore W1738174518C86803240 @default.
• W1738174518 hasConceptScore W1738174518C95444343 @default.
• W1738174518 hasIssue "2" @default.
• W1738174518 hasLocation W17381745181 @default.
• W1738174518 hasOpenAccess W1738174518 @default.
• W1738174518 hasPrimaryLocation W17381745181 @default.
• W1738174518 hasRelatedWork W183209599 @default.
• W1738174518 hasRelatedWork W2034270297 @default.
• W1738174518 hasRelatedWork W2034392767 @default.
• W1738174518 hasRelatedWork W2043831105 @default.
• W1738174518 hasRelatedWork W2124671617 @default.

• next