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- W1738248009 abstract "Publisher Summary This chapter presents the personal experience of the researcher on how the knowledge related to cancer developed from a state of ignorance of the composition of the gene to a state of considerable understanding of the nature and number of critical genetic events in carcinogenesis. Two tumors of children, Burkitt's lymphoma and retinoblastoma, have played key roles in the development of the understanding of genetic changes in human cancer. Initially, when DNA was shown to be a genetic material, two ideas on the origin of cancer were prevalent: somatic mutations or rare malignant transformation by an undetected latent virus. Since then, discoveries on tumor viruses and somatic mutations have combined to produce a new view of carcinogenesis in humans. The RNA tumor viruses revealed oncogenes and, in turn, their host counterparts, protooncogenes. Cytogenetic analysis led to the discovery of specific somatic mutations in these same protooncogenes, apparently unrelated to viral infection. The DNA tumor viruses revealed tumor antigen genes that had no counterparts in their hosts. The investigations of hereditary cancers and their corresponding nonhereditary forms led to the discovery of antioncogenes or tumor suppressor genes, two of which interact with the tumor antigens of DNA tumor viruses." @default.
- W1738248009 created "2016-06-24" @default.
- W1738248009 creator A5051498544 @default.
- W1738248009 date "1995-01-01" @default.
- W1738248009 modified "2023-10-13" @default.
- W1738248009 title "Mutation and Cancer: A Personal Odyssey" @default.
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