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• W1738338042 endingPage "5715" @default.
• W1738338042 startingPage "5705" @default.
• W1738338042 abstract "Two of the five immediate-early gene products, ICP4 and ICP27, expressed by herpes simplex virus type 1 have profound effects on viral gene expression and are absolutely essential for virus replication. Functional interactions between ICP4 and ICP27 may contribute to establishing the program of viral gene expression that ensues during lytic infection. To evaluate this possibility, viral mutants simultaneously deleted for ICP27 and defined functional domains of ICP4 were constructed. These mutant viruses allowed a comparison of gene expression as a function of different domains of ICP4 in the presence and absence of ICP27. Gene expression in the absence of both ICP4 and ICP27 was also examined. The results of this study demonstrate a clear involvement for ICP27 in the induction of early genes, in addition to its known role in enhancing late gene expression during viral infection. In the absence of both ICP4 and ICP27, viral early gene expression, as measured by the accumulation of thymidine kinase and ICP6 messages was dramatically reduced relative to the amounts of these messages seen in the absence of only ICP4. Therefore, elevated levels of early gene expression as a consequence of ICP27 occurred in the absence of any ICP4 activity. Evidence is also presented regarding the modulation of the ICP4 repression function by ICP27. When synthesized in the absence of ICP27, a mutant ICP4 protein was impaired in its ability to repress transcription from the L/ST promoter in the context of viral infection and in vitro. This defect correlated with the loss of the ability of this mutant protein to bind to its recognition sequence when produced in infected cells in the absence of ICP27. These observations indicate that ICP27 can regulate the activity of at least one domain of the ICP4 protein as well as contribute to elevated early gene expression independently of ICP4." @default.
• W1738338042 created "2016-06-24" @default.
• W1738338042 creator A5064289698 @default.
• W1738338042 creator A5068494706 @default.
• W1738338042 creator A5082742080 @default.
• W1738338042 date "1995-09-01" @default.
• W1738338042 modified "2023-09-26" @default.
• W1738338042 title "Functional interactions between herpes simplex virus immediate-early proteins during infection: gene expression as a consequence of ICP27 and different domains of ICP4" @default.
• W1738338042 cites W123433535 @default.
• W1738338042 cites W1490731141 @default.
• W1738338042 cites W1516191360 @default.
• W1738338042 cites W1540296073 @default.
• W1738338042 cites W1559441251 @default.
• W1738338042 cites W1576021204 @default.
• W1738338042 cites W1577666052 @default.
• W1738338042 cites W1582264883 @default.
• W1738338042 cites W1583466448 @default.
• W1738338042 cites W1603100906 @default.
• W1738338042 cites W1607589258 @default.
• W1738338042 cites W1645759506 @default.
• W1738338042 cites W1684170753 @default.
• W1738338042 cites W1690553754 @default.
• W1738338042 cites W1723491130 @default.
• W1738338042 cites W1733825645 @default.
• W1738338042 cites W1747817694 @default.
• W1738338042 cites W1763401036 @default.
• W1738338042 cites W1785757387 @default.
• W1738338042 cites W1788895899 @default.
• W1738338042 cites W1799661214 @default.
• W1738338042 cites W1817074176 @default.
• W1738338042 cites W1838326446 @default.
• W1738338042 cites W1854770036 @default.
• W1738338042 cites W1891768184 @default.
• W1738338042 cites W1900646268 @default.
• W1738338042 cites W1922286450 @default.
• W1738338042 cites W1927078541 @default.
• W1738338042 cites W1931233319 @default.
• W1738338042 cites W1934070818 @default.
• W1738338042 cites W1939294652 @default.
• W1738338042 cites W1954109446 @default.
• W1738338042 cites W1956073586 @default.
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• W1738338042 cites W1965372133 @default.
• W1738338042 cites W1970518530 @default.
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• W1738338042 cites W1993243592 @default.
• W1738338042 cites W2003624865 @default.
• W1738338042 cites W2010026543 @default.
• W1738338042 cites W2015265176 @default.
• W1738338042 cites W2018289835 @default.
• W1738338042 cites W2021458438 @default.
• W1738338042 cites W2033858354 @default.
• W1738338042 cites W2035779570 @default.
• W1738338042 cites W2045274476 @default.
• W1738338042 cites W2046261180 @default.
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• W1738338042 cites W2066276180 @default.
• W1738338042 cites W2066709551 @default.
• W1738338042 cites W2073073419 @default.
• W1738338042 cites W2084640063 @default.
• W1738338042 cites W2086996422 @default.
• W1738338042 cites W2090942794 @default.
• W1738338042 cites W2095557476 @default.
• W1738338042 cites W2095963288 @default.
• W1738338042 cites W2098074102 @default.
• W1738338042 cites W2100837269 @default.
• W1738338042 cites W2101202684 @default.
• W1738338042 cites W2103590684 @default.
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• W1738338042 cites W2118300475 @default.
• W1738338042 cites W2118929543 @default.
• W1738338042 cites W2119232680 @default.
• W1738338042 cites W2136793622 @default.
• W1738338042 cites W2145153782 @default.
• W1738338042 cites W2147990979 @default.
• W1738338042 cites W2149606427 @default.
• W1738338042 cites W2154947167 @default.
• W1738338042 cites W2157911990 @default.
• W1738338042 cites W2160726743 @default.
• W1738338042 cites W2163403783 @default.
• W1738338042 cites W2166195788 @default.
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• W1738338042 doi "https://doi.org/10.1128/jvi.69.9.5705-5715.1995" @default.
• W1738338042 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/189430" @default.
• W1738338042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7637016" @default.
• W1738338042 hasPublicationYear "1995" @default.
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