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• W1738362859 endingPage "170" @default.
• W1738362859 startingPage "160" @default.
• W1738362859 abstract "Bisphenol A (BPA) is used to manufacture plastics, including containers for food into which it may leach. High levels of exposure to this oestrogenic endocrine disruptor are associated with diabetes and heart disease. Oestrogen and oestrogen receptor modulators increase the activity of large conductance Ca(2+)/voltage-sensitive K(+) (Maxi-K; K(Ca)1.1) channels, but the effects of BPA on Maxi-K channels are unknown. We tested the hypothesis that BPA activates Maxi-K channels through a mechanism that depends upon the regulatory beta1 subunit.Patch-clamp recordings of Maxi-K channels were made in human and canine coronary smooth muscle cells as well as in AD-293 cells expressing pore-forming alpha or alpha plus beta1 subunits.BPA (10 microM) activated an outward current in smooth muscle cells that was inhibited by penitrem A (1 microM), a Maxi-K blocker. BPA increased Maxi-K activity in inside-out patches from coronary smooth muscle, but had no effect on single channel conductance. In AD-293 cells with Maxi-K channels composed of alpha subunits alone, 10 microM BPA did not affect channel activity. When channels in AD-293 cells contained beta1 subunits, 10 microM BPA increased channel activity. Effects of BPA were rapid (<1 min) and reversible. A higher concentration of BPA (100 microM) increased Maxi-K current independent of the beta1 subunit.Our data indicate that BPA increased the activity of Maxi-K channels and may represent a basis for some potential toxicological effects." @default.
• W1738362859 created "2016-06-24" @default.
• W1738362859 creator A5038570981 @default.
• W1738362859 creator A5059753019 @default.
• W1738362859 creator A5060547181 @default.
• W1738362859 date "2010-03-19" @default.
• W1738362859 modified "2023-09-26" @default.
• W1738362859 title "Bisphenol A activates Maxi-K (KCa1.1) channels in coronary smooth muscle" @default.
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• W1738362859 doi "https://doi.org/10.1111/j.1476-5381.2010.00687.x" @default.
• W1738362859 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2860216" @default.
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• W1738362859 hasPublicationYear "2010" @default.
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