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- W173840897 abstract "The authors sought to elucidate the role of draining cervical lymph nodes (CLNs) in corneal alloimmunity. Fully mismatched orthotopic corneal transplantation was performed in BALB/c hosts that had their CLNs excised before transplantation (CLN [−]). Normal hosts (CLN [+]), splenectomized mice (Sp [−]), and those without either CLNs or spleen (CLN [−]/Sp [−]) served as comparison groups. To determine the contribution of CLNs to alloimmunity more directly, CLN (−) mice were reconstituted by grafting LNs from other BALB/c mice to their cervical lymphatic chains, thus deriving CLN (−/+) mice. Tetramethyl rhodamine isothiocyanate’s (TRITC) flow to draining CLNs was used as a measure of afferent lymph flow. Graft survival and allospecific delayed-type hypersensitivity (DTH) were used as measures of alloreactivity. Fifty percent of normal control and 12% of Sp (−) hosts accepted the allografts. In contrast, 100% of CLN (−) and 88% of CLN (−)/Sp (−) hosts accepted allografts indefinitely (P < 0.01). All CLN (−) hosts failed to demonstrate allospecific DTH (P < 0.001). CLN (−/+) mice reconstituted with LN from naive animals showed graft survival rates and DTH responses that were indistinguishable from those of naive CLN (+) mice. Mice reconstituted with CLNs from hosts with rejected corneal grafts had swift rejection of subsequent corneal grafts and exhibited strong donor-specific DTH. Mice reconstituted with CLNs from hosts with accepted corneal grafts showed rejection in naive CLN (+) hosts. The authors conclude that draining CLNs play a critical role in allosensitization and rejection. In contrast to the spleen, draining CLNs do not appear to play a critical role in tolerance induction in corneal transplantation.—Thomas J. Liesegang" @default.
- W173840897 created "2016-06-24" @default.
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- W173840897 date "2002-01-01" @default.
- W173840897 modified "2023-09-27" @default.
- W173840897 title "The critical role of lymph nodes in corneal alloimmunization and graft rejection." @default.
- W173840897 doi "https://doi.org/10.1016/s0002-9394(01)01349-6" @default.
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