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- W173845416 abstract "Tuberculosis (TB), which is caused by Mycobacterium tuberculosis, is one of the major public health problems worldwide. Cure rates of >95% can be achieved with modern anti-TB treatment, which comprises short-course chemotherapy regimens containing isoniazid (INH), rifampicin (RMP), pyrazinamide (PZA), and ethambutol (EMB) for patients with drug-susceptible TB strains. Despite the availability of potent drugs, some patients do not respond to treatment or develop serious adverse effects.Although many nongenetic factors influence the effects of medications, interindividual differences in drug response have been linked to sequence variants in genes encoding drug-metabolizing enzymes, drug transporters, or drug targets. Pharmacogenomic studies of drugs used in the treatment of TB can promote understanding of intersubject variations in treatment response. In this chapter, we look at pharmacogenomic data on anti-TB drugs from different settings to provide better insight into the role of pharmacogenomics in the treatment of TB, thereby enhancing efficacy and limiting toxicity of existing anti-TB medications.A review of different studies has established the importance of pharmacogenomics in TB. Studies from different settings show that pharmacogenomics plays a significant role in INH metabolism, affecting both treatment efficacy and ADR frequency. There are limited data on single-nucleotide polymorphisms that influence plasma RMP concentrations. No data are available on the other first-line drugs, EMB and PZA. It would be useful for treating physicians to incorporate pharmacogenomics in clinical TB trials to understand the factors that influence therapeutic success and the occurrence of adverse drug reactions." @default.
- W173845416 created "2016-06-24" @default.
- W173845416 creator A5050947550 @default.
- W173845416 creator A5076624513 @default.
- W173845416 date "2014-01-01" @default.
- W173845416 modified "2023-10-17" @default.
- W173845416 title "Tuberculosis" @default.
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