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- W1738542476 abstract "Publisher Summary This chapter discusses adverse effects of corticotrophins and corticosteroids. The interaction of the corticosteroid with its receptor may play an important role in the variation in biological potency between different analogues. Life-threatening bronchospasm has been observed in some asthmatic patients following intravenous administration of hydrocortisone. A case of leuko-erythroblastosis following withdrawal from corticosteroid therapy has been observed. Due to the pronounced day-to-day changes in white blood cell count in patients treated with alternate-day corticosteroids, it has been recommended that blood samples should be taken for cell counts before the morning corticosteroid dose. An ultrastructural investigation of leukoderma following a peri- and intra-articular injection in the elbow showed functioning melanocytes, but a failure of keratinocytes in capturing the melanosomes. This investigation gives an explanation for both the delay in appearance of symptoms and the usually complete remission after a couple of months. Disorders of menstruation are a common complaint in fertile women receiving higher doses of corticosteroids. There seems to be a difference among steroids in this respect. Administration of dexamethasone to normal subjects results in a negative nitrogen balance due to increased urinary urea excretion, with a concomitant increase in blood alanine and arginine." @default.
- W1738542476 created "2016-06-24" @default.
- W1738542476 creator A5016815393 @default.
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- W1738542476 date "1978-01-01" @default.
- W1738542476 modified "2023-09-27" @default.
- W1738542476 title "Corticotrophins and corticosteroids" @default.
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