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• W173859529 abstract "Articular cartilage of adult individuals has a limited capacity for repair. Although not well studied, it appears likely that in many cases joint surface defects (JSD) progress over the years, ultimately evolving into frank osteoarthritic joints. Developing parameters that will identify the individuals at risk, i.e., those individuals who will develop osteoarthritis after joint injury, is a challenge in modern medicine, and using new technologies such as genomics, proteomics and bioinformatics may lead in the coming decade to the identification of prognostic predictors. In addition, to prevent this joint deterioration, several therapeutic strategies have been developed, microfracture, mosaicplasty, and autologous chondrocyte transplantation (ACT) presently being the most popular. The microfracture technique is mostly reserved to small size lesions, and consists in perforating the bottom of the JSD to recruit skeletal precursors present in the underlying bone marrow. The mosaicplasty procedure consists of collecting several osteochondral plugs obtained from low weight bearing areas of the joint, and subsequently fitting them into the JSD, like in a mosaic. This transforms a relatively large defect into several small defects that can be repaired spontaneously by the surrounding tissue and by the invading bone marrow derived skeletal precursors/mesenchymal stem cells [1]." @default.
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• W173859529 date "2002-01-01" @default.
• W173859529 modified "2023-10-11" @default.
• W173859529 title "Identification and characterization of human cell populations capable of forming stable hyaline cartilage in vivo" @default.
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• W173859529 doi "https://doi.org/10.1007/978-3-0348-8133-3_7" @default.
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