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- W173866311 abstract "The physiological role for, and the ligand(s) of, TCRγδ cells remain intense fields of investigation. The selective tissue localization of some subsets of TCRγδ cells (Allison et al. 1988, Tonegawa et al. 1989, Goodman and Lefrancois 1988, Bucy et al. 1988) as well as the relatively restricted T cell receptor usage in those tissues has led to the suggestion that this specialized T cell subset recognizes non-polymorphic MHC or conserved antigens (Asarnow et al. 1988). In fact, the identification of bacterial antigens (Janis et al. 1989, Kabelitz et al. 1990), more specifically heat shock proteins (Born et al. 1990, Rajasekar et al. 1990, Holoshitz et al. 1989), as potential ligands for TCRγδ cells has solidified the notion that these cells may indeed play a unique role in the immune system. However, many of these studies have been limited to an analysis of selected TCRγδ populations often localized in epithelial tissue or newborn thymus. In this brief review we would like to summarize our data with regards to the potential diversity of splenic and lymph node-derived TCRγδ cells, compare the general observations of ligand specificity for these cells and those of TCRαβ cells, and finally, to present one approach towards beginning to determine the effect of MHC and non-MHC genes on TCRγδ repertoire development." @default.
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- W173866311 date "1991-01-01" @default.
- W173866311 modified "2023-09-26" @default.
- W173866311 title "Ligand Specificity and Repertoire Development of Murine TCRγδ Cells" @default.
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- W173866311 doi "https://doi.org/10.1007/978-3-642-76492-9_18" @default.
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