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• W1738892734 endingPage "4327" @default.
• W1738892734 startingPage "4318" @default.
• W1738892734 abstract "Abstract BCL3 encodes a protein with close homology to IκB proteins and interacts with p50 NF-κB homodimers. However, the regulation and transcriptional activity of BCL3 remain ill-defined. We observed here that interleukin-9 (IL-9) and IL-4, but not IL-2 or IL-3, transcriptionally upregulated BCL3 expression in T cells and mast cells. BCL3 induction by IL-9 was detected as soon as 4 hours after stimulation and appeared to be dependent on the Jak/STAT pathway. IL-9 stimulation was associated with an increase in p50 homodimers DNA binding activity, which was mimicked by stableBCL3 expression. This contrasts with tumor necrosis factor (TNF)-dependent NF-κB activation, which occurs earlier, involves p65/p50 dimers, and is dependent on IκB degradation. Moreover, IL-9 stimulation or BCL3 transient transfection similarly inhibited NF-κB–mediated transcription in response to TNF. Taken together, our observations show a new regulatory pathway for the NF-κB transcription factors through STAT-dependent upregulation ofBCL3 gene expression." @default.
• W1738892734 created "2016-06-24" @default.
• W1738892734 creator A5036695915 @default.
• W1738892734 creator A5038862163 @default.
• W1738892734 creator A5041759664 @default.
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• W1738892734 date "1999-06-15" @default.
• W1738892734 modified "2023-10-18" @default.
• W1738892734 title "Interleukin-9 Regulates NF-κB Activity Through BCL3 Gene Induction" @default.
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• W1738892734 doi "https://doi.org/10.1182/blood.v93.12.4318" @default.
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• W1738892734 hasPublicationYear "1999" @default.
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