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• W1738956265 abstract "Platelets play an important role in normal haemostasis halting blood flow immediately after injuries through four fundamental different mechanisms: adhesion, aggregation, secretion, and expression of procoagulant activity. First, in the presence of vascular damage, platelets adhere to the connective tissue and, particularly when the damage occurs in vessels with a low shear rate, to subendothelial collagen, fibronectin and laminin. On the other hand, when damage occurs in regions with a high shear rate, platelet adhesion requires the presence of subendothelial von Willebrand factor (VWF) and specific platelet receptors, such as the glycoprotein Ib/IX/V (GPIb/IX/V) complex. In any case, following initial adhesion, platelets aggregate to complete the formation of a solid haemostatic plug. Platelet aggregation requires stimulation by agonists such as ADP, thrombin, collagen, or epinephrine, as well as the presence of calcium or magnesium ions and specific plasma proteins (fibrinogen, VWF and the glycoprotein IIb/IIIa (GPIIb/IIIa) complex). Platelet stimulation results in the generation of intracellular second messengers that convey the stimulus back to the platelet surface, exposing protein binding sites on GPIIb/IIIa. Fibrinogen (or VWF) then binds to GPIIb/IIIa and cross-links adjacent platelets to produce platelet aggregates, following platelet secretion and the elaboration of platelet procoagulant activity. In platelet disorders caused by a reduction in the number of platelets (thrombocytopenia) (Table I) or by platelet function defects (thrombocytopathies) (Table II), bleeding generally occurs immediately after injury, primarily in the skin, mucous membranes, nose, and gastrointestinal and urinary tracts and, generally, does not involve joints and muscles. Congenital disorders are uncommon and sometimes may be misdiagnosed with acquired disorders, which are much more frequently encountered in clinical practice. The differential diagnosis between congenital or acquired platelet disorders is often very complex and requires medical experience and a careful assessment of the patient’s personal and family history of bleeding episodes. A lifelong bleeding diathesis may suggest a congenital platelet disorder, which is often first recognised during childhood, but an onset in adulthood does not exclude a congenital defect. Because technological progress in laboratory practices and greater information about platelet functions have increased the specificity and accuracy of diagnosis of platelet disorders, a large number of cases has been identified recently. In this review, we describe current knowledge on congenital platelets disorders with regards to granule packaging, signalling and platelet coagulant function, and hereditary thrombocytopenias in order to improve information available for research and clinical practice.Table IClassification of thrombocytopathies" @default.
• W1738956265 created "2016-06-24" @default.
• W1738956265 creator A5001323477 @default.
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• W1738956265 date "2009-10-01" @default.
• W1738956265 modified "2023-09-22" @default.
• W1738956265 title "Inherited platelet disorders: thrombocytopenias and thrombocytopathies." @default.
• W1738956265 cites W120226665 @default.
• W1738956265 cites W122876140 @default.
• W1738956265 cites W1481442945 @default.
• W1738956265 cites W1530154863 @default.
• W1738956265 cites W1550140963 @default.
• W1738956265 cites W1555059577 @default.
• W1738956265 cites W1557889858 @default.
• W1738956265 cites W1590912031 @default.
• W1738956265 cites W1598647766 @default.
• W1738956265 cites W1602182436 @default.
• W1738956265 cites W1608256683 @default.
• W1738956265 cites W1785730200 @default.
• W1738956265 cites W1830764534 @default.
• W1738956265 cites W1835149745 @default.
• W1738956265 cites W1964304230 @default.
• W1738956265 cites W1966696537 @default.
• W1738956265 cites W1967821057 @default.
• W1738956265 cites W1978978873 @default.
• W1738956265 cites W1981881077 @default.
• W1738956265 cites W1981974890 @default.
• W1738956265 cites W1982865150 @default.
• W1738956265 cites W1983253822 @default.
• W1738956265 cites W1983369802 @default.
• W1738956265 cites W1988095542 @default.
• W1738956265 cites W1991274147 @default.
• W1738956265 cites W1991569711 @default.
• W1738956265 cites W1995229467 @default.
• W1738956265 cites W1995501959 @default.
• W1738956265 cites W1997315893 @default.
• W1738956265 cites W2001814436 @default.
• W1738956265 cites W2002247698 @default.
• W1738956265 cites W2006468333 @default.
• W1738956265 cites W2006808005 @default.
• W1738956265 cites W2007826232 @default.
• W1738956265 cites W2007946052 @default.
• W1738956265 cites W2008637083 @default.
• W1738956265 cites W2009366052 @default.
• W1738956265 cites W2011479097 @default.
• W1738956265 cites W2012153447 @default.
• W1738956265 cites W2012717492 @default.
• W1738956265 cites W2013944173 @default.
• W1738956265 cites W2023552723 @default.
• W1738956265 cites W2034083722 @default.
• W1738956265 cites W2035419236 @default.
• W1738956265 cites W2035589350 @default.
• W1738956265 cites W2041418974 @default.
• W1738956265 cites W2046504591 @default.
• W1738956265 cites W2048065205 @default.
• W1738956265 cites W2051622215 @default.
• W1738956265 cites W2056100508 @default.
• W1738956265 cites W2060305564 @default.
• W1738956265 cites W2063381463 @default.
• W1738956265 cites W2067222107 @default.
• W1738956265 cites W207251429 @default.
• W1738956265 cites W2087235653 @default.
• W1738956265 cites W2100678593 @default.
• W1738956265 cites W2101480907 @default.
• W1738956265 cites W2103771488 @default.
• W1738956265 cites W2108100481 @default.
• W1738956265 cites W2116179076 @default.
• W1738956265 cites W2121698778 @default.
• W1738956265 cites W2133125037 @default.
• W1738956265 cites W2145329209 @default.
• W1738956265 cites W2147524033 @default.
• W1738956265 cites W2148011592 @default.
• W1738956265 cites W2150325933 @default.
• W1738956265 cites W2154336224 @default.
• W1738956265 cites W2157293452 @default.
• W1738956265 cites W2164046385 @default.
• W1738956265 cites W2166775494 @default.
• W1738956265 cites W2171332720 @default.
• W1738956265 cites W2181359324 @default.
• W1738956265 cites W2251525188 @default.
• W1738956265 cites W2270669221 @default.
• W1738956265 cites W2280792657 @default.
• W1738956265 cites W239986433 @default.
• W1738956265 cites W2405928432 @default.
• W1738956265 cites W2407567100 @default.
• W1738956265 cites W2409717523 @default.
• W1738956265 cites W2413578523 @default.
• W1738956265 cites W88624808 @default.
• W1738956265 doi "https://doi.org/10.2450/2009.0078-08" @default.
• W1738956265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2782805" @default.
• W1738956265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20011639" @default.
• W1738956265 hasPublicationYear "2009" @default.
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