FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W173950401> ?p ?o ?g. }

• W173950401 abstract "The κ opioid receptors (KOR) provide desirable substrates for targeted therapy and unraveling pathways responsible for mediating addictive behavior. Kappa opioid agonists offer a means to modulate the effects of stimulant drugs. However, there currently are no available approved agents or compounds for these purposes. Thus, the specific aim of this project was to identify subtype specific small molecule agonists of the human KOR. Such agonists might be useful in elucidating different signaling modalities for kappa receptors, but more importantly, they might also be partial agonists that will facilitate the discovery of new molecular scaffolds for kappa antagonists. In this report, we describe the discovery and optimization of two novel agonists for the KOR, the small molecular probes ML139 (CID-5236771) and ML138 (CID-44601470), each of which are greater than 100-fold selective over the mu-(µ) and delta (δ) opioid subtype receptors. Furthermore, these probes and their analogs represent novel chemical classes compared to current literature agonists, with potentially unique pharmacology that may serve as interesting tools to advance addiction research." @default.
• W173950401 created "2016-06-24" @default.
• W173950401 creator A5001936516 @default.
• W173950401 creator A5003372721 @default.
• W173950401 creator A5003815380 @default.
• W173950401 creator A5007698609 @default.
• W173950401 creator A5012049476 @default.
• W173950401 creator A5018256113 @default.
• W173950401 creator A5020364108 @default.
• W173950401 creator A5034968976 @default.
• W173950401 creator A5035496277 @default.
• W173950401 creator A5046064743 @default.
• W173950401 creator A5049300475 @default.
• W173950401 creator A5061920697 @default.
• W173950401 creator A5065480463 @default.
• W173950401 creator A5072771672 @default.
• W173950401 creator A5087938892 @default.
• W173950401 creator A5088422127 @default.
• W173950401 creator A5088773747 @default.
• W173950401 creator A5089193987 @default.
• W173950401 creator A5090001946 @default.
• W173950401 creator A5091303907 @default.
• W173950401 date "2010-10-04" @default.
• W173950401 modified "2023-09-24" @default.
• W173950401 title "Selective KOP Receptor Agonists: Probe 1 & Probe 2" @default.
• W173950401 cites W2015782150 @default.
• W173950401 cites W2021137848 @default.
• W173950401 cites W2033640369 @default.
• W173950401 cites W2043858733 @default.
• W173950401 cites W2083362331 @default.
• W173950401 cites W2084210364 @default.
• W173950401 cites W2101693074 @default.
• W173950401 hasPublicationYear "2010" @default.
• W173950401 type Work @default.
• W173950401 sameAs 173950401 @default.
• W173950401 citedByCount "0" @default.
• W173950401 crossrefType "journal-article" @default.
• W173950401 hasAuthorship W173950401A5001936516 @default.
• W173950401 hasAuthorship W173950401A5003372721 @default.
• W173950401 hasAuthorship W173950401A5003815380 @default.
• W173950401 hasAuthorship W173950401A5007698609 @default.
• W173950401 hasAuthorship W173950401A5012049476 @default.
• W173950401 hasAuthorship W173950401A5018256113 @default.
• W173950401 hasAuthorship W173950401A5020364108 @default.
• W173950401 hasAuthorship W173950401A5034968976 @default.
• W173950401 hasAuthorship W173950401A5035496277 @default.
• W173950401 hasAuthorship W173950401A5046064743 @default.
• W173950401 hasAuthorship W173950401A5049300475 @default.
• W173950401 hasAuthorship W173950401A5061920697 @default.
• W173950401 hasAuthorship W173950401A5065480463 @default.
• W173950401 hasAuthorship W173950401A5072771672 @default.
• W173950401 hasAuthorship W173950401A5087938892 @default.
• W173950401 hasAuthorship W173950401A5088422127 @default.
• W173950401 hasAuthorship W173950401A5088773747 @default.
• W173950401 hasAuthorship W173950401A5089193987 @default.
• W173950401 hasAuthorship W173950401A5090001946 @default.
• W173950401 hasAuthorship W173950401A5091303907 @default.
• W173950401 hasConcept C135285700 @default.
• W173950401 hasConcept C14397066 @default.
• W173950401 hasConcept C169760540 @default.
• W173950401 hasConcept C170493617 @default.
• W173950401 hasConcept C184389661 @default.
• W173950401 hasConcept C185592680 @default.
• W173950401 hasConcept C2778938600 @default.
• W173950401 hasConcept C2779886867 @default.
• W173950401 hasConcept C2781063702 @default.
• W173950401 hasConcept C43587935 @default.
• W173950401 hasConcept C48856860 @default.
• W173950401 hasConcept C55493867 @default.
• W173950401 hasConcept C70721500 @default.
• W173950401 hasConcept C71924100 @default.
• W173950401 hasConcept C74187038 @default.
• W173950401 hasConcept C86803240 @default.
• W173950401 hasConcept C98274493 @default.
• W173950401 hasConceptScore W173950401C135285700 @default.
• W173950401 hasConceptScore W173950401C14397066 @default.
• W173950401 hasConceptScore W173950401C169760540 @default.
• W173950401 hasConceptScore W173950401C170493617 @default.
• W173950401 hasConceptScore W173950401C184389661 @default.
• W173950401 hasConceptScore W173950401C185592680 @default.
• W173950401 hasConceptScore W173950401C2778938600 @default.
• W173950401 hasConceptScore W173950401C2779886867 @default.
• W173950401 hasConceptScore W173950401C2781063702 @default.
• W173950401 hasConceptScore W173950401C43587935 @default.
• W173950401 hasConceptScore W173950401C48856860 @default.
• W173950401 hasConceptScore W173950401C55493867 @default.
• W173950401 hasConceptScore W173950401C70721500 @default.
• W173950401 hasConceptScore W173950401C71924100 @default.
• W173950401 hasConceptScore W173950401C74187038 @default.
• W173950401 hasConceptScore W173950401C86803240 @default.
• W173950401 hasConceptScore W173950401C98274493 @default.
• W173950401 hasLocation W1739504011 @default.
• W173950401 hasOpenAccess W173950401 @default.
• W173950401 hasPrimaryLocation W1739504011 @default.
• W173950401 hasRelatedWork W1491842333 @default.
• W173950401 hasRelatedWork W1992961161 @default.
• W173950401 hasRelatedWork W2012966353 @default.
• W173950401 hasRelatedWork W2024791543 @default.
• W173950401 hasRelatedWork W2026649804 @default.
• W173950401 hasRelatedWork W2051345524 @default.

• next