FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1740229968> ?p ?o ?g. }

• W1740229968 abstract "The ability to anticipate future events and to modify erroneous anticipatory actions is crucial for the survival of any organism. Both theoretical and empirical lines of evidence implicate the cerebellum in this ability. It is often suggested that the cerebellum acquires “expectations” or “internal models”. However, except in a metaphorical sense, the cerebellum, which consists of a set of interconnected nerve cells, cannot contain “internal models” or “have expectations”. The aim of this thesis is to untangle these metaphors by translating them back into neurophysiological cause and effect relationships. This task is approached from within the paradigm of classical conditioning, in which a subject, through repeated presentations of a conditional stimulus, followed by an unconditional stimulus, acquires a conditioned response. Importantly, the conditioned response is timed so that it anticipates the unconditioned response. Available neurophysiological evidence suggests that Purkinje cells, in the cerebellar cortex, generate the conditioned response. In addition, Purkinje cells provide negative feedback to the IO, which is a relay for the unconditional stimulus, via the nucleo-olivary pathway. Purkinje cells can therefore regulate the intensity of the signal derived from the unconditional stimulus, which, in turn, decides subsequent plasticity. Hence, as learning progresses, the IO signal will become weaker and weaker due to increasing negative feedback from Purkinje cells. Thus, in an important sense, learning induced changes in Purkinje cell activity constitute an “expectation” or “anticipation” of a future event (the unconditional stimulus), and, consistent with theoretical models, future learning depends on the accuracy of this expectation. Paper 1 in this thesis show that learned changes in Purkinje cells influences subsequent IO activity. The second paper show that, depending on the number of pulses it contains, the signal from the IO to the Purkinje cells can either cause acquisition or extinction. In the third paper we present evidence that can potentially help explain overexpectation, a behavioral phenomenon, which have for long been elusive. Collectively these papers advance our understanding of the feedback mechanisms that govern cerebellar learning and it proposes a potential solution to some long standing behavioral conundrums. (Less)" @default.
• W1740229968 created "2016-06-24" @default.
• W1740229968 creator A5052534123 @default.
• W1740229968 date "2014-01-01" @default.
• W1740229968 modified "2023-09-25" @default.
• W1740229968 title "Feedback control of cerebellar learning" @default.
• W1740229968 cites W133568568 @default.
• W1740229968 cites W1528959312 @default.
• W1740229968 cites W1552535744 @default.
• W1740229968 cites W160989634 @default.
• W1740229968 cites W1965741585 @default.
• W1740229968 cites W1966147798 @default.
• W1740229968 cites W1967929733 @default.
• W1740229968 cites W1970774281 @default.
• W1740229968 cites W1971542097 @default.
• W1740229968 cites W1972466164 @default.
• W1740229968 cites W1975561989 @default.
• W1740229968 cites W1978515738 @default.
• W1740229968 cites W1980842275 @default.
• W1740229968 cites W1981262586 @default.
• W1740229968 cites W1984397875 @default.
• W1740229968 cites W1984917351 @default.
• W1740229968 cites W1989226479 @default.
• W1740229968 cites W1993227369 @default.
• W1740229968 cites W1994952022 @default.
• W1740229968 cites W2001799450 @default.
• W1740229968 cites W2002671673 @default.
• W1740229968 cites W2003761697 @default.
• W1740229968 cites W2005359015 @default.
• W1740229968 cites W2008464801 @default.
• W1740229968 cites W2008470349 @default.
• W1740229968 cites W2009327045 @default.
• W1740229968 cites W2009635803 @default.
• W1740229968 cites W2010341991 @default.
• W1740229968 cites W2010753031 @default.
• W1740229968 cites W2012028550 @default.
• W1740229968 cites W2012198383 @default.
• W1740229968 cites W2012441424 @default.
• W1740229968 cites W2017464919 @default.
• W1740229968 cites W2021000234 @default.
• W1740229968 cites W2025205736 @default.
• W1740229968 cites W2031402048 @default.
• W1740229968 cites W2031646826 @default.
• W1740229968 cites W2031714533 @default.
• W1740229968 cites W2032943627 @default.
• W1740229968 cites W2037593288 @default.
• W1740229968 cites W2039905869 @default.
• W1740229968 cites W2041141391 @default.
• W1740229968 cites W2047452260 @default.
• W1740229968 cites W2048630476 @default.
• W1740229968 cites W2050066016 @default.
• W1740229968 cites W2051736447 @default.
• W1740229968 cites W2054143989 @default.
• W1740229968 cites W2054751290 @default.
• W1740229968 cites W2055850746 @default.
• W1740229968 cites W2055914072 @default.
• W1740229968 cites W2058734747 @default.
• W1740229968 cites W2065773795 @default.
• W1740229968 cites W2065912874 @default.
• W1740229968 cites W2068828473 @default.
• W1740229968 cites W2071155636 @default.
• W1740229968 cites W2074202447 @default.
• W1740229968 cites W2076133271 @default.
• W1740229968 cites W2078437991 @default.
• W1740229968 cites W2081422689 @default.
• W1740229968 cites W2088158546 @default.
• W1740229968 cites W2089197692 @default.
• W1740229968 cites W2092707652 @default.
• W1740229968 cites W2093653777 @default.
• W1740229968 cites W2099763786 @default.
• W1740229968 cites W2100929470 @default.
• W1740229968 cites W2101347364 @default.
• W1740229968 cites W2103019454 @default.
• W1740229968 cites W2103617625 @default.
• W1740229968 cites W2104321133 @default.
• W1740229968 cites W2106614622 @default.
• W1740229968 cites W2112556865 @default.
• W1740229968 cites W2126483315 @default.
• W1740229968 cites W2129382165 @default.
• W1740229968 cites W2129679993 @default.
• W1740229968 cites W2131856835 @default.
• W1740229968 cites W2136304630 @default.
• W1740229968 cites W2137345241 @default.
• W1740229968 cites W2141731733 @default.
• W1740229968 cites W2144367924 @default.
• W1740229968 cites W2146555760 @default.
• W1740229968 cites W2147270524 @default.
• W1740229968 cites W2148486620 @default.
• W1740229968 cites W2155051950 @default.
• W1740229968 cites W2155897992 @default.
• W1740229968 cites W2158420012 @default.
• W1740229968 cites W2160328559 @default.
• W1740229968 cites W2162078915 @default.
• W1740229968 cites W2163243513 @default.
• W1740229968 cites W2164509516 @default.
• W1740229968 cites W2166100493 @default.
• W1740229968 cites W2167560779 @default.
• W1740229968 cites W2168828075 @default.
• W1740229968 cites W2489296777 @default.
• W1740229968 cites W3171586585 @default.

• next