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• W1740661736 abstract "Coated-platelets, representing a subset of platelets with procoagulant potential, are elevated in patients with non-lacunar ischemic stroke and decreased in patients with spontaneous intracerebral hemorrhage. However, within the non-lacunar patient population there are individuals with lower levels of coated-platelets, which raises the possibility that these individuals would be susceptible to early hemorrhagic transformation (HT) of ischemic stroke.Because extremes in coated-platelet potential may be associated with either thrombotic or hemorrhagic events, we undertook a pilot study to investigate whether there is an association between coated-platelet production and the presence of early HT in patients with non-lacunar ischemic stroke.Coated-platelet levels were determined in 115 consecutive eligible patients with a diagnosis of non-lacunar ischemic stroke. Early HT was determined on CT scan examination and confirmed by MRI studies. The distribution of coated-platelet levels was summarized using the median and interquartile range (25th-75th percentiles) and compared statistically between patients with and without early HT using the non-parametric Wilcoxon rank sum test.The median coated-platelet level in all non-lacunar stroke patients was 38.0% (interquartile range 30.5-48.3%). Early HT was detected in 11 patients (9.6%), and these patients had significantly lower coated-platelet levels compared with those without early HT [median 25.1% (interquartile range 20.4-35.5%) vs. 39.2% (31.6-49.5%), P = 0.003].Lower levels of coated-platelets are associated with the presence of early HT in patients with non-lacunar ischemic stroke." @default.
• W1740661736 created "2016-06-24" @default.
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• W1740661736 date "2010-06-01" @default.
• W1740661736 modified "2023-10-17" @default.
• W1740661736 title "Lower coated‐platelet levels are associated with early hemorrhagic transformation in patients with non‐lacunar brain infarction" @default.
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• W1740661736 doi "https://doi.org/10.1111/j.1538-7836.2010.03851.x" @default.
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