Matches in SemOpenAlex for { <https://semopenalex.org/work/W174090865> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W174090865 endingPage "202" @default.
- W174090865 startingPage "195" @default.
- W174090865 abstract "Periodontitis is a localized infectious disease caused by periodontopathic bacteria such as Porphyromonas gingivalis (P. gingivalis), and the severity correlates to significance of immune responses. Recently, it has been reported that periodontitis is associated with the development of systemic disease such as diabetes and atherosclerosis because of increasing invasion of oral pathogens to the circulation. However, the association between local and systemic infectious responses is still unclear. In the present study, we examined the differences of biological responses in animals with or without bacterial infection. After Balb/c mice were infected subcutaneously with live P. gingivalis W83, serum, skin and liver were collected according to experimental protocol. The skin and liver tissues were observed pathologically by haematoxylin-eosin staining, and serum IL-6 levels were measured using ELISA method. Throughout the experimental period, conditions of the mice were observed continuously. As expected, severe infiltration of leukocytes were observed at inflamed skin corresponding to the number of bacterial challenges. Although no inflammatory appearance of skin was observed, serum IL-6 levels were increased dramatically (P <0.01, Student's t-test) and liver tissues were injured in the mice without bacterial challenge. Interestingly, although severe inflammatory appearance of the skin was observed, serum IL-6 levels were not increased and no inflammatory responses were observed in the liver of the 3-times bacterially challenged group. Importantly, immunoglobulin G against P. gingivalis W83 was detected in the blood of mice with 3-times bacterial challenge corresponding to improvement of weight loss and survival. In conclusion, although multiple infections develop severe localized inflammation, the immune system should be sufficient to protect the systemic inflammatory responses." @default.
- W174090865 created "2016-06-24" @default.
- W174090865 creator A5003411797 @default.
- W174090865 creator A5004356125 @default.
- W174090865 creator A5037350891 @default.
- W174090865 creator A5040394868 @default.
- W174090865 creator A5040429486 @default.
- W174090865 creator A5042243476 @default.
- W174090865 creator A5048669756 @default.
- W174090865 creator A5049686289 @default.
- W174090865 creator A5052011362 @default.
- W174090865 creator A5060424035 @default.
- W174090865 creator A5062030782 @default.
- W174090865 creator A5072819590 @default.
- W174090865 creator A5081005700 @default.
- W174090865 creator A5088580819 @default.
- W174090865 date "2011-09-02" @default.
- W174090865 modified "2023-10-08" @default.
- W174090865 title "Immune responses to porphyromonas gingivalis infection suppress systemic inflammatory response in experimental murine model." @default.
- W174090865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21880208" @default.
- W174090865 hasPublicationYear "2011" @default.
- W174090865 type Work @default.
- W174090865 sameAs 174090865 @default.
- W174090865 citedByCount "3" @default.
- W174090865 countsByYear W1740908652012 @default.
- W174090865 countsByYear W1740908652013 @default.
- W174090865 countsByYear W1740908652020 @default.
- W174090865 crossrefType "journal-article" @default.
- W174090865 hasAuthorship W174090865A5003411797 @default.
- W174090865 hasAuthorship W174090865A5004356125 @default.
- W174090865 hasAuthorship W174090865A5037350891 @default.
- W174090865 hasAuthorship W174090865A5040394868 @default.
- W174090865 hasAuthorship W174090865A5040429486 @default.
- W174090865 hasAuthorship W174090865A5042243476 @default.
- W174090865 hasAuthorship W174090865A5048669756 @default.
- W174090865 hasAuthorship W174090865A5049686289 @default.
- W174090865 hasAuthorship W174090865A5052011362 @default.
- W174090865 hasAuthorship W174090865A5060424035 @default.
- W174090865 hasAuthorship W174090865A5062030782 @default.
- W174090865 hasAuthorship W174090865A5072819590 @default.
- W174090865 hasAuthorship W174090865A5081005700 @default.
- W174090865 hasAuthorship W174090865A5088580819 @default.
- W174090865 hasConcept C126322002 @default.
- W174090865 hasConcept C159654299 @default.
- W174090865 hasConcept C203014093 @default.
- W174090865 hasConcept C2776914184 @default.
- W174090865 hasConcept C2777300124 @default.
- W174090865 hasConcept C2780183776 @default.
- W174090865 hasConcept C2780385504 @default.
- W174090865 hasConcept C71924100 @default.
- W174090865 hasConcept C8891405 @default.
- W174090865 hasConceptScore W174090865C126322002 @default.
- W174090865 hasConceptScore W174090865C159654299 @default.
- W174090865 hasConceptScore W174090865C203014093 @default.
- W174090865 hasConceptScore W174090865C2776914184 @default.
- W174090865 hasConceptScore W174090865C2777300124 @default.
- W174090865 hasConceptScore W174090865C2780183776 @default.
- W174090865 hasConceptScore W174090865C2780385504 @default.
- W174090865 hasConceptScore W174090865C71924100 @default.
- W174090865 hasConceptScore W174090865C8891405 @default.
- W174090865 hasIssue "2" @default.
- W174090865 hasLocation W1740908651 @default.
- W174090865 hasOpenAccess W174090865 @default.
- W174090865 hasPrimaryLocation W1740908651 @default.
- W174090865 hasRelatedWork W116026772 @default.
- W174090865 hasRelatedWork W147818956 @default.
- W174090865 hasRelatedWork W168987098 @default.
- W174090865 hasRelatedWork W1764412896 @default.
- W174090865 hasRelatedWork W199598178 @default.
- W174090865 hasRelatedWork W2116833475 @default.
- W174090865 hasRelatedWork W2267697526 @default.
- W174090865 hasRelatedWork W2399808392 @default.
- W174090865 hasRelatedWork W2400814279 @default.
- W174090865 hasRelatedWork W2403460198 @default.
- W174090865 hasRelatedWork W2412122779 @default.
- W174090865 hasRelatedWork W2414714390 @default.
- W174090865 hasRelatedWork W2417982431 @default.
- W174090865 hasRelatedWork W2565966187 @default.
- W174090865 hasRelatedWork W2573785295 @default.
- W174090865 hasRelatedWork W2575185119 @default.
- W174090865 hasRelatedWork W2576707569 @default.
- W174090865 hasRelatedWork W265489015 @default.
- W174090865 hasRelatedWork W90615487 @default.
- W174090865 hasRelatedWork W93742189 @default.
- W174090865 hasVolume "25" @default.
- W174090865 isParatext "false" @default.
- W174090865 isRetracted "false" @default.
- W174090865 magId "174090865" @default.
- W174090865 workType "article" @default.