Matches in SemOpenAlex for { <https://semopenalex.org/work/W17414462> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W17414462 endingPage "7" @default.
- W17414462 startingPage "1" @default.
- W17414462 abstract "Crystalline silica was recently classified as a human carcinogen by the International Agency for Research on Cancer (IARC). However, the direct genotoxic effect of silica in humans remains unclear. We examined the p53 and K-ras gene mutations in lung cancer in workers with silicosis (LCWS). DNA was extracted from paraffin-embedded tissues and examined by PCR-RFLP, PCR-SSCP, and DNA sequencing. The mutation frequencies of p53 gene were high, but the mutation distributions in exons and among the histological types of LCWS differed from those of common (i.e., not silicosis-related) lung cancer. Furthermore, no mutations in codon 12 of K-ras gene (predominant in common lung cancer) were found in LCWS. These findings in the mutational spectrum support a carcinogenic effect of silica dust at the DNA molecular level." @default.
- W17414462 created "2016-06-24" @default.
- W17414462 creator A5030148992 @default.
- W17414462 creator A5034637071 @default.
- W17414462 creator A5038453915 @default.
- W17414462 creator A5057780725 @default.
- W17414462 creator A5060006944 @default.
- W17414462 creator A5069530115 @default.
- W17414462 creator A5077283974 @default.
- W17414462 date "2000-01-01" @default.
- W17414462 modified "2023-10-12" @default.
- W17414462 title "A distinct mutational spectrum of p53 and K-ras genes in lung cancer of workers with silicosis." @default.
- W17414462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10905501" @default.
- W17414462 hasPublicationYear "2000" @default.
- W17414462 type Work @default.
- W17414462 sameAs 17414462 @default.
- W17414462 citedByCount "7" @default.
- W17414462 countsByYear W174144622012 @default.
- W17414462 countsByYear W174144622016 @default.
- W17414462 crossrefType "journal-article" @default.
- W17414462 hasAuthorship W17414462A5030148992 @default.
- W17414462 hasAuthorship W17414462A5034637071 @default.
- W17414462 hasAuthorship W17414462A5038453915 @default.
- W17414462 hasAuthorship W17414462A5057780725 @default.
- W17414462 hasAuthorship W17414462A5060006944 @default.
- W17414462 hasAuthorship W17414462A5069530115 @default.
- W17414462 hasAuthorship W17414462A5077283974 @default.
- W17414462 hasConcept C102306862 @default.
- W17414462 hasConcept C104317684 @default.
- W17414462 hasConcept C114246631 @default.
- W17414462 hasConcept C121608353 @default.
- W17414462 hasConcept C142724271 @default.
- W17414462 hasConcept C153911025 @default.
- W17414462 hasConcept C168007829 @default.
- W17414462 hasConcept C2776256026 @default.
- W17414462 hasConcept C2777811718 @default.
- W17414462 hasConcept C2993769243 @default.
- W17414462 hasConcept C2994225774 @default.
- W17414462 hasConcept C36823959 @default.
- W17414462 hasConcept C49105822 @default.
- W17414462 hasConcept C501734568 @default.
- W17414462 hasConcept C502942594 @default.
- W17414462 hasConcept C54355233 @default.
- W17414462 hasConcept C552990157 @default.
- W17414462 hasConcept C71924100 @default.
- W17414462 hasConcept C86803240 @default.
- W17414462 hasConceptScore W17414462C102306862 @default.
- W17414462 hasConceptScore W17414462C104317684 @default.
- W17414462 hasConceptScore W17414462C114246631 @default.
- W17414462 hasConceptScore W17414462C121608353 @default.
- W17414462 hasConceptScore W17414462C142724271 @default.
- W17414462 hasConceptScore W17414462C153911025 @default.
- W17414462 hasConceptScore W17414462C168007829 @default.
- W17414462 hasConceptScore W17414462C2776256026 @default.
- W17414462 hasConceptScore W17414462C2777811718 @default.
- W17414462 hasConceptScore W17414462C2993769243 @default.
- W17414462 hasConceptScore W17414462C2994225774 @default.
- W17414462 hasConceptScore W17414462C36823959 @default.
- W17414462 hasConceptScore W17414462C49105822 @default.
- W17414462 hasConceptScore W17414462C501734568 @default.
- W17414462 hasConceptScore W17414462C502942594 @default.
- W17414462 hasConceptScore W17414462C54355233 @default.
- W17414462 hasConceptScore W17414462C552990157 @default.
- W17414462 hasConceptScore W17414462C71924100 @default.
- W17414462 hasConceptScore W17414462C86803240 @default.
- W17414462 hasIssue "1-2" @default.
- W17414462 hasLocation W174144621 @default.
- W17414462 hasOpenAccess W17414462 @default.
- W17414462 hasPrimaryLocation W174144621 @default.
- W17414462 hasRelatedWork W1201292968 @default.
- W17414462 hasRelatedWork W17414462 @default.
- W17414462 hasRelatedWork W2014479212 @default.
- W17414462 hasRelatedWork W2351845239 @default.
- W17414462 hasRelatedWork W2374188380 @default.
- W17414462 hasRelatedWork W2374950459 @default.
- W17414462 hasRelatedWork W2384774992 @default.
- W17414462 hasRelatedWork W2392191458 @default.
- W17414462 hasRelatedWork W2396310232 @default.
- W17414462 hasRelatedWork W2419448289 @default.
- W17414462 hasVolume "19" @default.
- W17414462 isParatext "false" @default.
- W17414462 isRetracted "false" @default.
- W17414462 magId "17414462" @default.
- W17414462 workType "article" @default.