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- W17422182 abstract "This chapter focuses on two cell biological problems—(1) the mechanism by which the cell select the messenger RNAs (mRNAs) of secretory proteins for translation on membrane bound ribosomes; (2) the specialized mechanism by which nascent chains on membrane bound ribosomes are translocated across the endoplasmic reticulum (ER) membrane. The signal hypothesis is suggested as a solution for both of these problems related to translocation of secretory proteins across the ER membrane. The evidence in favor of the signal hypothesis comes from several experimental approaches. The most powerful approach is the construction of a reconstituted heterologous cell-free system capable of translocation of nascent secretory proteins across membranes. This allows dissection of the role of various components in the translational process. The chapter explains two distinct assays for translocation across membranes in cell-free systems—(1) protection from proteolysis, and (2) principle of membrane asymmetry. These cell-free systems permit one to test several features of the signal hypothesis. This approach is used to study a large number of proteins." @default.
- W17422182 created "2016-06-24" @default.
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- W17422182 date "1980-01-01" @default.
- W17422182 modified "2023-09-30" @default.
- W17422182 title "Early Events in the Biosynthesis of Secretory and Membrane Proteins: The Signal Hypothesis" @default.
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- W17422182 doi "https://doi.org/10.1016/b978-0-12-571136-4.50018-8" @default.
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