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- W17423089 abstract "For adult vertebrates, it is not known whether respiratory-related pacemaker neurons exist and play a critical role in rhythm generation. To address this question, brainstems from adult turtles were isolated in vitro and respiratory motor bursts were recorded on hypoglossal (XII) nerve roots. Extracellular recordings of respiratory-related neurons were acquired using multichannel silicon electrodes. While bathed in artificial cerebrospinal fluid, neurons (n=87) exhibited phasic behavior in relation to the XII motor bursts. Synaptic transmission was blocked with antagonists for GABAA (bicuculline), glycine (strychnine), AMPA (CNQX), and NMDA (APV) receptors. During synaptic transmission blockade, 14/87 neurons continued to fire with rhythmic bursts of action potentials and were considered putative pacemaker neurons. When [K+] was increased to 6.0–9.0 mM during ongoing synaptic blockade, 9/10 pacemaker neurons increased burst frequency and action potential firing rates within the bursts. Application of a mu-opioid agonist (DAMGO) decreased burst frequency in 3/4 pacemaker neurons. These results suggest that respiratory pacemaker neurons, which respond to increased [K+] and mu-opioid receptor activation, exist in adult turtles. We hypothesize that these pacemaker neurons may be critical for rhythm generation." @default.
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- W17423089 date "2008-03-01" @default.
- W17423089 modified "2023-09-25" @default.
- W17423089 title "Respiratory‐related pacemaker neurons in isolated turtle brainstems in vitro" @default.
- W17423089 doi "https://doi.org/10.1096/fasebj.22.1_supplement.755.15" @default.
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