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- W1742574429 abstract "Abstract To develop cytolytic effector functions, CD8 + T lymphocytes need to recognize specific Ag/MHC class I complexes in the context of costimuli on Ag‐presenting DC. Thereafter they differentiate into effector and memory CTL able to confer protection against pathogen infection. Using transgenic mice with DC‐selective MHC class I expression and DC‐specific versus ubiquitous vaccination regimen, we found that DC are sufficient to prime CTL responses. However, Ag recognition on parenchymal non‐professional APC negatively affected CD8 + T‐cell responses in mice by inducing expression of the pro‐apoptotic bcl2‐family member bim in CTL. This unexpected induction of apoptosis in the early phase of effector CTL accumulation lead to suboptimal clonal burst size and diminished long‐term memory. Thus, our data demonstrate that effector CTL differentiation and apoptosis are regulated independently. Moreover, Ag distribution on cells other than DC critically reduces CTL responses." @default.
- W1742574429 created "2016-06-24" @default.
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- W1742574429 date "2010-04-01" @default.
- W1742574429 modified "2023-10-18" @default.
- W1742574429 title "Parenchymal cells critically curtail cytotoxic T-cell responses by inducing Bim-mediated apoptosis" @default.
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- W1742574429 doi "https://doi.org/10.1002/eji.200939485" @default.
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