FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1742822977> ?p ?o ?g. }

• W1742822977 abstract "Neuroendocrine tumors (NET) are known for an overexpression of somatostatin receptors (SSTR). In light of very few and partially contradictory publications, the present study aims to achieve a definite immunohistochemical (IHC) quantification and assessment of the distribution of all five SSTR-subtypes on NET and to evaluate an implementable scoring system, comparing the immunoreactive score of Remmele and Stegner (IRS) to the Her2-score. In 21 patients 40 different tumor tissues were IHC analysed using polyclonal antibodies for SSTR1 and 3-5 and the monoclonal antibody UMB-1 for SSTR2A. SSTR expression was quantitatively evaluated according to HER2-score and IRS, correlated among each other and to the maximum standardized uptake value (SUVmax) in tumor lesions as measured by PET/CT using 68Ga-DOTA-NOC.According to the IRS, the expression of SSTR2A and 3 predominated equally with 84%, followed by SSTR4 (44%) and SSTR1 and 5 (32%). With the Her2-scoring system the most frequent subtype was found to be SSTR2A (68%), followed by SSTR3 (64%), SSTR1 (44%), SSTR5 (40%), and SSTR4 (36%). The IRS-classification and the Her2-score were found to be statistically comparable, and their correlation is highly significant for each SSTR assessment (p<0.01).The results of the analyses revealed heterogeneous expression patterns. SSTR2A and 3 were highly expressed, demonstrating the importance of SSTR for diagnostics and therapy. Relatively high frequency of SSTR3 and 4 on NET give reasons to try pansomatostatin analogues for therapy rather than concentrating only on the SSTR2A. Statistically, none of the immunohistochemical scores was superior. However, due the heterogeneity of the cytoplasmic staining justice we propose the IRS as a uniform scoring scheme for IHC NET diagnostic." @default.
• W1742822977 created "2016-06-24" @default.
• W1742822977 creator A5009887617 @default.
• W1742822977 creator A5012183393 @default.
• W1742822977 creator A5038796778 @default.
• W1742822977 creator A5051446048 @default.
• W1742822977 creator A5054870153 @default.
• W1742822977 creator A5062424480 @default.
• W1742822977 creator A5075109656 @default.
• W1742822977 creator A5079676133 @default.
• W1742822977 date "2012-01-01" @default.
• W1742822977 modified "2023-10-17" @default.
• W1742822977 title "Comparing of IRS and Her2 as immunohistochemical scoring schemes in gastroenteropancreatic neuroendocrine tumors." @default.
• W1742822977 cites W1534718635 @default.
• W1742822977 cites W1748597660 @default.
• W1742822977 cites W1912234690 @default.
• W1742822977 cites W1957124990 @default.
• W1742822977 cites W1963940642 @default.
• W1742822977 cites W1972392589 @default.
• W1742822977 cites W1988220230 @default.
• W1742822977 cites W1996231078 @default.
• W1742822977 cites W2028427973 @default.
• W1742822977 cites W2043448289 @default.
• W1742822977 cites W2045681528 @default.
• W1742822977 cites W2053578362 @default.
• W1742822977 cites W2071161519 @default.
• W1742822977 cites W2080916065 @default.
• W1742822977 cites W2102119911 @default.
• W1742822977 cites W2105738798 @default.
• W1742822977 cites W2107914252 @default.
• W1742822977 cites W2112545770 @default.
• W1742822977 cites W2115686439 @default.
• W1742822977 cites W2135726172 @default.
• W1742822977 cites W2147989740 @default.
• W1742822977 cites W2157744078 @default.
• W1742822977 cites W2158474413 @default.
• W1742822977 cites W2165936138 @default.
• W1742822977 cites W2340386540 @default.
• W1742822977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3341681" @default.
• W1742822977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22558472" @default.
• W1742822977 hasPublicationYear "2012" @default.
• W1742822977 type Work @default.
• W1742822977 sameAs 1742822977 @default.
• W1742822977 citedByCount "64" @default.
• W1742822977 countsByYear W17428229772013 @default.
• W1742822977 countsByYear W17428229772014 @default.
• W1742822977 countsByYear W17428229772015 @default.
• W1742822977 countsByYear W17428229772016 @default.
• W1742822977 countsByYear W17428229772017 @default.
• W1742822977 countsByYear W17428229772018 @default.
• W1742822977 countsByYear W17428229772019 @default.
• W1742822977 countsByYear W17428229772020 @default.
• W1742822977 countsByYear W17428229772021 @default.
• W1742822977 countsByYear W17428229772022 @default.
• W1742822977 countsByYear W17428229772023 @default.
• W1742822977 crossrefType "journal-article" @default.
• W1742822977 hasAuthorship W1742822977A5009887617 @default.
• W1742822977 hasAuthorship W1742822977A5012183393 @default.
• W1742822977 hasAuthorship W1742822977A5038796778 @default.
• W1742822977 hasAuthorship W1742822977A5051446048 @default.
• W1742822977 hasAuthorship W1742822977A5054870153 @default.
• W1742822977 hasAuthorship W1742822977A5062424480 @default.
• W1742822977 hasAuthorship W1742822977A5075109656 @default.
• W1742822977 hasAuthorship W1742822977A5079676133 @default.
• W1742822977 hasConcept C126322002 @default.
• W1742822977 hasConcept C142724271 @default.
• W1742822977 hasConcept C143998085 @default.
• W1742822977 hasConcept C150008808 @default.
• W1742822977 hasConcept C159654299 @default.
• W1742822977 hasConcept C203014093 @default.
• W1742822977 hasConcept C204232928 @default.
• W1742822977 hasConcept C2776297358 @default.
• W1742822977 hasConcept C2779066768 @default.
• W1742822977 hasConcept C64980429 @default.
• W1742822977 hasConcept C71924100 @default.
• W1742822977 hasConcept C80115893 @default.
• W1742822977 hasConcept C86803240 @default.
• W1742822977 hasConcept C956191 @default.
• W1742822977 hasConceptScore W1742822977C126322002 @default.
• W1742822977 hasConceptScore W1742822977C142724271 @default.
• W1742822977 hasConceptScore W1742822977C143998085 @default.
• W1742822977 hasConceptScore W1742822977C150008808 @default.
• W1742822977 hasConceptScore W1742822977C159654299 @default.
• W1742822977 hasConceptScore W1742822977C203014093 @default.
• W1742822977 hasConceptScore W1742822977C204232928 @default.
• W1742822977 hasConceptScore W1742822977C2776297358 @default.
• W1742822977 hasConceptScore W1742822977C2779066768 @default.
• W1742822977 hasConceptScore W1742822977C64980429 @default.
• W1742822977 hasConceptScore W1742822977C71924100 @default.
• W1742822977 hasConceptScore W1742822977C80115893 @default.
• W1742822977 hasConceptScore W1742822977C86803240 @default.
• W1742822977 hasConceptScore W1742822977C956191 @default.
• W1742822977 hasLocation W17428229771 @default.
• W1742822977 hasOpenAccess W1742822977 @default.
• W1742822977 hasPrimaryLocation W17428229771 @default.
• W1742822977 hasRelatedWork W2019710161 @default.
• W1742822977 hasRelatedWork W2048178827 @default.
• W1742822977 hasRelatedWork W2065910084 @default.
• W1742822977 hasRelatedWork W2079951871 @default.
• W1742822977 hasRelatedWork W2157744078 @default.

• next