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- W17432203 abstract "Clinical and neuropathological studies have shown evidence of subgroups and heterogeneity in the presentation of Alzheimer’s disease (AD). To quantify the degenerating process, we have been able to set up a reliable experimental protocol based upon an immunoblot analysis of pathological tau proteins, referred to as tau 55, 64 and 69, which are known to be early and reliable markers of AD. These markers allowed us to map easily the distribution of the neurofibrillary degeneration. The mapping was performed in the 46 Brodmann areas of the brains from five Alzheimer patients with similar duration of the disease. In all cases, the detection of tau 55, 64 and 69 was positive in all areas except in primary visual cortex (area 17) for two patients. The quantities of abnormal tau were especially strong in temporal neocortical and limbic areas and were higher in associative cortex than in primary sensory cortex. Using this quantitative approach, we observed three factors of heterogeneity:1.occipital and frontal lobes were sometimes less affected by the degenerating process while limbic and temporal lobes were constantly and strongly affected, showing a heterogenous pattern along the rostrocaudal axis;2.the comparison of the amounts of abnormal tau proteins found in the temporal area (AB21) of 10 AD patients with different ages of onset was also undertaken. Generally we observed a decrease of the quantity of abnormal tau in late onset cases, but the brain of one very old AD patient contained huge amounts of abnormal tau proteins in all neocortical areas;3.despite a very short duration of illness (18 months), one patient exhibited a general and large amount of abnormal tau proteins expressed in all cortical areas and in the neostriatum. We conclude that our biochemical approach is very convenient to apprehend the extent and the intensity of the degenerating process. This approach demonstrates the heterogeneity of AD." @default.
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- W17432203 date "1992-01-01" @default.
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- W17432203 title "Distribution of Tau-PHF in Brodmann Areas Reveals a Heterogeneity of the Degenerating Process in Rostro-Caudal Regions and as a Function of Age" @default.
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- W17432203 doi "https://doi.org/10.1007/978-3-642-46776-9_16" @default.
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