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• W1743288452 abstract "SUMMARY Because of the strong causal relationship between persistent infections of human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN) and cancer, HPVtesting has been proposed for improvement of cervical screening programs, including triaging and follow-up after treatment for CIN. We developed two new methods for HPV-testing with genotyping: A high-throughput HPV genotyping method that uses mass spectrometry for detection of the products of type-specific mass extend reactions, and a method with particularly sensitive detection of a broad spectrum of HPV-types, also in the case of multiple infections, that uses type-specific probes coupled to fluorescent beads for detection on the Luminex platform. The utility of HPV-testing was evaluated in 3 different studies: A general primer PCR-based genotyping method and the commercial Hybrid Capture (HCII) assay were compared for sensitivity and specificity for detection of CIN in secondary screening and in follow-up after treatment for cervical dysplasia. The sensitivities were high for both methods, although somewhat higher for the PCR method, but the concordance between the methods was substantial. The performance of HPV-genotyping for prediction of recurrence after treatment for CIN was compared to that of cytology. Only HPV-genotyping could predict all cases of CIN grade II or worse in histopathology, and all cases of CIN I or worse in cytology during follow-up had persistence of HPV. The applicability of HPV-genotyping was also evaluated in a secondary screening setting. Different high-risk HPV types had substantial differences in risk for presence of CIN III or worse among women with ASCUS and CIN I in cytology, suggesting that HPV typing could be useful for further optimization of ASCUS/CIN I triaging strategies. In summary, 2 HPV-genotyping methods with different applicability have been developed and validated. We also conclude that HPV genotyping is useful both in secondary screening as well as in follow-up after treatment for CIN. (Less)" @default.
• W1743288452 created "2016-06-24" @default.
• W1743288452 creator A5009113367 @default.
• W1743288452 date "2008-01-01" @default.
• W1743288452 modified "2023-09-27" @default.
• W1743288452 title "Human papillomavirus testing and its application in cervical cancer prevention" @default.
• W1743288452 cites W1488061308 @default.
• W1743288452 cites W1493333110 @default.
• W1743288452 cites W1501034426 @default.
• W1743288452 cites W1529992354 @default.
• W1743288452 cites W1539426772 @default.
• W1743288452 cites W1554821140 @default.
• W1743288452 cites W156003141 @default.
• W1743288452 cites W1569876593 @default.
• W1743288452 cites W1573394606 @default.
• W1743288452 cites W1583082810 @default.
• W1743288452 cites W1594666494 @default.
• W1743288452 cites W1601489651 @default.
• W1743288452 cites W1699837866 @default.
• W1743288452 cites W1716807906 @default.
• W1743288452 cites W1720536632 @default.
• W1743288452 cites W1722478811 @default.
• W1743288452 cites W1760520378 @default.
• W1743288452 cites W1767781328 @default.
• W1743288452 cites W1801314933 @default.
• W1743288452 cites W1822333858 @default.
• W1743288452 cites W1829177623 @default.
• W1743288452 cites W1830126998 @default.
• W1743288452 cites W1831319429 @default.
• W1743288452 cites W1839148143 @default.
• W1743288452 cites W1947425084 @default.
• W1743288452 cites W1959508910 @default.
• W1743288452 cites W1966243834 @default.
• W1743288452 cites W1966832944 @default.
• W1743288452 cites W1967254492 @default.
• W1743288452 cites W1969280226 @default.
• W1743288452 cites W1970296166 @default.
• W1743288452 cites W1970479838 @default.
• W1743288452 cites W1973803676 @default.
• W1743288452 cites W1973961759 @default.
• W1743288452 cites W1975565930 @default.
• W1743288452 cites W1976051908 @default.
• W1743288452 cites W1977077361 @default.
• W1743288452 cites W1977141892 @default.
• W1743288452 cites W1977393774 @default.
• W1743288452 cites W1977740257 @default.
• W1743288452 cites W1977942351 @default.
• W1743288452 cites W1979055772 @default.
• W1743288452 cites W1980506400 @default.
• W1743288452 cites W1980750660 @default.
• W1743288452 cites W1981135622 @default.
• W1743288452 cites W1982155122 @default.
• W1743288452 cites W1984785242 @default.
• W1743288452 cites W1985584979 @default.
• W1743288452 cites W1986850683 @default.
• W1743288452 cites W1987235414 @default.
• W1743288452 cites W1987350137 @default.
• W1743288452 cites W1987495826 @default.
• W1743288452 cites W1988274510 @default.
• W1743288452 cites W1994172446 @default.
• W1743288452 cites W1994274263 @default.
• W1743288452 cites W1997384168 @default.
• W1743288452 cites W1999436974 @default.
• W1743288452 cites W2001956724 @default.
• W1743288452 cites W2006272640 @default.
• W1743288452 cites W2006571834 @default.
• W1743288452 cites W2006924252 @default.
• W1743288452 cites W2008604978 @default.
• W1743288452 cites W2008750108 @default.
• W1743288452 cites W2009115624 @default.
• W1743288452 cites W2012228655 @default.
• W1743288452 cites W2012735071 @default.
• W1743288452 cites W2013068290 @default.
• W1743288452 cites W2014166788 @default.
• W1743288452 cites W2016775797 @default.
• W1743288452 cites W2017296685 @default.
• W1743288452 cites W2018646351 @default.
• W1743288452 cites W2019902320 @default.
• W1743288452 cites W2024897738 @default.
• W1743288452 cites W2025021599 @default.
• W1743288452 cites W2025589177 @default.
• W1743288452 cites W2026756123 @default.
• W1743288452 cites W2028967730 @default.
• W1743288452 cites W2029735450 @default.
• W1743288452 cites W2031135517 @default.
• W1743288452 cites W2031457470 @default.
• W1743288452 cites W2031841054 @default.
• W1743288452 cites W2032952575 @default.
• W1743288452 cites W2033552856 @default.
• W1743288452 cites W2034579809 @default.
• W1743288452 cites W2035097569 @default.
• W1743288452 cites W2035599345 @default.
• W1743288452 cites W2036351016 @default.
• W1743288452 cites W2036882978 @default.
• W1743288452 cites W2038125204 @default.
• W1743288452 cites W2040115433 @default.
• W1743288452 cites W2040614603 @default.
• W1743288452 cites W2041725513 @default.
• W1743288452 cites W2042176139 @default.
• W1743288452 cites W2043711648 @default.

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