FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1743444304> ?p ?o ?g. }

• W1743444304 abstract "5-Lipoxygenase (5-LOX) catalyses two steps in the biosynthesis of leukotrienes (LTs), lipid mediators of inflammation derived from arachidonic acid. LTs function in normal host defence, and have pathophysiological roles in chronic inflammatory diseases, as asthma and atherosclerosis. Also, possible effects of 5-LOX products in relation to tumorigenesis have been described. 5-LOX is also involved in the biosynthesis of anti-inflammatory/pro-resolving lipoxins. 5-LOX is mainly expressed in myeloid and lymphoid cells and its expression is upregulated during cell differentiation. Cellular 5-LOX activity is regulated in a complex manner and depends on cellular localisation, phosphorylation, the intracellular calcium concentration and the redox status of the cell. Thus, insight regarding the biochemistry of 5-LOX is relevant for better understanding of normal physiology, and for development of pharmacotherapy.Key Concepts: Lipoxygenases oxygenate polyunsaturated fatty acids.5-LOX produces 5-HPETE, leukotrienes and together with other dioxygenases lipoxins.The regulatory C2-like domain binds Ca2+, diacylglycerols and phosphatidylcholine and regulates the activity of the catalytic domain.5-LOX interacts with various proteins such as FLAP, CLP and Dicer.The 5-lipoxygenase pathway is part of the innate immune system.5-LOX products are involved in inflammation, allergic reactions, development of cardiovascular disease as well as certain types of cancer.Keywords:5-lipoxygenase;leukotrienes;lipoxins;5-HETE;arachidonic acid;C2-like domain;nonhaem iron" @default.
• W1743444304 created "2016-06-24" @default.
• W1743444304 creator A5045395183 @default.
• W1743444304 creator A5082078699 @default.
• W1743444304 creator A5082257614 @default.
• W1743444304 date "2014-10-15" @default.
• W1743444304 modified "2023-09-30" @default.
• W1743444304 title "Recent Advances on 5-Lipoxygenase Biochemistry" @default.
• W1743444304 cites W1565831347 @default.
• W1743444304 cites W1901434497 @default.
• W1743444304 cites W1966576495 @default.
• W1743444304 cites W1970533314 @default.
• W1743444304 cites W1971572251 @default.
• W1743444304 cites W1973141368 @default.
• W1743444304 cites W1973477882 @default.
• W1743444304 cites W1975207791 @default.
• W1743444304 cites W1982121912 @default.
• W1743444304 cites W1988303362 @default.
• W1743444304 cites W1993209206 @default.
• W1743444304 cites W1998506436 @default.
• W1743444304 cites W2000866756 @default.
• W1743444304 cites W2004357717 @default.
• W1743444304 cites W2005872355 @default.
• W1743444304 cites W2008238416 @default.
• W1743444304 cites W2019422381 @default.
• W1743444304 cites W2019604250 @default.
• W1743444304 cites W2019608971 @default.
• W1743444304 cites W2020442377 @default.
• W1743444304 cites W2021283405 @default.
• W1743444304 cites W2024176341 @default.
• W1743444304 cites W2025785462 @default.
• W1743444304 cites W2028849618 @default.
• W1743444304 cites W2044151897 @default.
• W1743444304 cites W2045221081 @default.
• W1743444304 cites W2052937262 @default.
• W1743444304 cites W2055717324 @default.
• W1743444304 cites W2056496442 @default.
• W1743444304 cites W2059290365 @default.
• W1743444304 cites W2061431191 @default.
• W1743444304 cites W2064068820 @default.
• W1743444304 cites W2065145374 @default.
• W1743444304 cites W2065297082 @default.
• W1743444304 cites W2065925334 @default.
• W1743444304 cites W2066173314 @default.
• W1743444304 cites W2066516520 @default.
• W1743444304 cites W2068561324 @default.
• W1743444304 cites W2069340847 @default.
• W1743444304 cites W2070809839 @default.
• W1743444304 cites W2077047375 @default.
• W1743444304 cites W2081452901 @default.
• W1743444304 cites W2084728352 @default.
• W1743444304 cites W2085959335 @default.
• W1743444304 cites W2087053437 @default.
• W1743444304 cites W2087557590 @default.
• W1743444304 cites W2088996645 @default.
• W1743444304 cites W2096925306 @default.
• W1743444304 cites W2102136911 @default.
• W1743444304 cites W2113237775 @default.
• W1743444304 cites W2123773797 @default.
• W1743444304 cites W2127810324 @default.
• W1743444304 cites W2129280925 @default.
• W1743444304 cites W2143350004 @default.
• W1743444304 cites W2149565581 @default.
• W1743444304 cites W2153202165 @default.
• W1743444304 cites W2155041831 @default.
• W1743444304 cites W2165648585 @default.
• W1743444304 cites W2553273299 @default.
• W1743444304 cites W4233185382 @default.
• W1743444304 cites W4237270851 @default.
• W1743444304 doi "https://doi.org/10.1002/9780470015902.a0024630" @default.
• W1743444304 hasPublicationYear "2014" @default.
• W1743444304 type Work @default.
• W1743444304 sameAs 1743444304 @default.
• W1743444304 citedByCount "0" @default.
• W1743444304 crossrefType "reference-entry" @default.
• W1743444304 hasAuthorship W1743444304A5045395183 @default.
• W1743444304 hasAuthorship W1743444304A5082078699 @default.
• W1743444304 hasAuthorship W1743444304A5082257614 @default.
• W1743444304 hasConcept C181199279 @default.
• W1743444304 hasConcept C185592680 @default.
• W1743444304 hasConcept C203014093 @default.
• W1743444304 hasConcept C2776914184 @default.
• W1743444304 hasConcept C2778078955 @default.
• W1743444304 hasConcept C2780857362 @default.
• W1743444304 hasConcept C55493867 @default.
• W1743444304 hasConcept C86803240 @default.
• W1743444304 hasConcept C90342290 @default.
• W1743444304 hasConcept C95444343 @default.
• W1743444304 hasConceptScore W1743444304C181199279 @default.
• W1743444304 hasConceptScore W1743444304C185592680 @default.
• W1743444304 hasConceptScore W1743444304C203014093 @default.
• W1743444304 hasConceptScore W1743444304C2776914184 @default.
• W1743444304 hasConceptScore W1743444304C2778078955 @default.
• W1743444304 hasConceptScore W1743444304C2780857362 @default.
• W1743444304 hasConceptScore W1743444304C55493867 @default.
• W1743444304 hasConceptScore W1743444304C86803240 @default.
• W1743444304 hasConceptScore W1743444304C90342290 @default.
• W1743444304 hasConceptScore W1743444304C95444343 @default.
• W1743444304 hasLocation W17434443041 @default.
• W1743444304 hasOpenAccess W1743444304 @default.

• next