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• W1743778826 abstract "Background: Serum concentration of 25-hydroxy vitamin D (25(OH) D) is the major circulating form of vitamin D and the best indicator of assessment of vitamin D status. It reflects vitamin D obtained from food and supplements and has a fairly long circulating half-life of 15 days. 25(OH)D levels do not indicate the amount of vitamin D stored in body tissues. The non-classical actions of vitamin D which are anti-proliferation, pro-differentiation, pro-apoptosis, anti-inflammation, and immune regulation, have received great attention during the past decade. Vitamin D insufficiency has been associated with the occurrence of various types of cancer, the association between vitamin D status and hepatocellular carcinoma (HCC) has not been well investigated. Objective: This study was designed to evaluate the role of serum vitamin D concentration in the diagnosis of HCC and to consider its potential role as a novel marker for HCC compared with AFP. Subjects and methods: This study was conducted on 80 Egyptian subjects and classified into two groups: HCC group (n = 40), in addition to forty age and sex matched healthy individuals as a control group. HCC was diagnosed histologically or by imaging. Serum 25(OH)D and plasma AFP levels were quantitatively determined using ELISA technique for all participants together with full clinical assessment, liver biochemical profile, viral markers, conventional ultrasound (US) and abdominal triphasic CT scan Results: Serum 25(OH)D concentration was significantly lower in HCC patients (3ng/ml) than controls (27.25 ng/ml) (P =0.001). Furthermore, the cutoff level of 25(OH) D for diagnosis of HCC in this study was <6.5 ng/ml, with a sensitivity and specificity of 88.5% and 100% respectively. The diagnostic sensitivity of AFP at a cutoff of <37ng/ml was 55% and the specificity was 100%. Conclusions: Serum 25(OH)D could be a potential diagnostic marker for HCC and is relatively comparative to AFP. Keywords Hepatocellular carcinoma (HCC), 25-hydroxy vitamin D(25(OH) D), Alpha-fetoprotein (AFP)" @default.
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• W1743778826 date "2014-01-01" @default.
• W1743778826 modified "2023-10-06" @default.
• W1743778826 title "25-Hydroxy Vitamin D: Novel Biomarker for the Diagnosis of Hepatocellular Carcinoma" @default.
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