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• W1743910632 abstract "CD 4 + T follicular helper ( T FH ) cells are central for generation of long‐term B ‐cell immunity. A defining phenotypic attribute of T FH cells is the expression of the chemokine R CXCR 5, and T FH cells are typically identified by co‐expression of CXCR 5 together with other markers such as PD‐1, ICOS, and Bcl‐6. Herein, we report high‐level expression of the nutrient transporter folate R 4 ( FR 4) on T FH cells in acute viral infection. Distinct from the expression profile of conventional T FH markers, FR 4 was highly expressed by naive CD 4 + T cells, was downregulated after activation and subsequently re‐expressed on T FH cells. Furthermore, FR 4 expression was maintained, albeit at lower levels, on memory T FH cells. Comparative gene expression profiling of FR 4 hi versus FR 4 lo Ag‐specific CD 4 + effector T cells revealed a molecular signature consistent with T FH and T H 1 subsets, respectively. Interestingly, genes involved in the purine metabolic pathway, including the ecto‐enzyme CD 73, were enriched in T FH cells compared with T H 1 cells, and phenotypic analysis confirmed expression of CD 73 on T FH cells. As there is now considerable interest in developing vaccines that would induce optimal T FH cell responses, the identification of two novel cell surface markers should be useful in characterization and identification of T FH cells following vaccination and infection." @default.
• W1743910632 created "2016-06-24" @default.
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• W1743910632 date "2013-10-14" @default.
• W1743910632 modified "2023-10-15" @default.
• W1743910632 title "Identification of novel markers for mouse CD4⁺T follicular helper cells" @default.
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• W1743910632 doi "https://doi.org/10.1002/eji.201343469" @default.
• W1743910632 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3947211" @default.
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