FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1744050156> ?p ?o ?g. }

• W1744050156 endingPage "2602" @default.
• W1744050156 startingPage "2597" @default.
• W1744050156 abstract "Lung cancer is the major cause of cancer-related death worldwide, and 80 % of them are non-small cell lung cancer (NSCLC) cases. Gremlin, a bone morphogenetic protein (BMP) antagonist, is overexpressed in various cancerous tissues; however, little is known about the roles of Gremlin in lung carcinogenesis, and it remains unclear whether Gremlin expression may associate with EGFR-TKI resistance. In this study, expression of Gremlin mRNA and protein in matched tumor and normal lung specimens are quantified by quantitative real-time PCR and western blot. The functional role of Gremlin in NSCLC cells was evaluated by interference RNA (siRNA). The effects of Silenced Gremlin on the resistant PC-9/GR cell line were investigated by proliferation and apoptosis analysis compared with control PC-9 cells. Our results found that Gremlin expression levels were higher in NSCLC tissues, and Gremlin was more highly expressed in PC-9/GR cells compared to PC-9 cells. Knocking down of Gremlin in PC-9/GR cells decreased cell proliferation and increased the expression of BMP7 protein. In addition, Gremlin silencing significantly potentiated apoptosis induced by gefitinib in PC-9/GR with Gremlin knockdown compared to PC-9 transfected with control shRNA, suggesting Gremlin contributes to gefitinib resistance in NSCLC. Gremlin might be explored as a candidate of therapeutic target for modulating EGFR-TKI sensitivity in NSCLC." @default.
• W1744050156 created "2016-06-24" @default.
• W1744050156 creator A5004609798 @default.
• W1744050156 creator A5010702785 @default.
• W1744050156 creator A5014807310 @default.
• W1744050156 creator A5020251798 @default.
• W1744050156 creator A5028688827 @default.
• W1744050156 creator A5061088955 @default.
• W1744050156 creator A5070180435 @default.
• W1744050156 date "2015-09-21" @default.
• W1744050156 modified "2023-09-25" @default.
• W1744050156 title "Overexpression of Gremlin promotes non-small cell lung cancer progression" @default.
• W1744050156 cites W1937015993 @default.
• W1744050156 cites W1986825521 @default.
• W1744050156 cites W1989348032 @default.
• W1744050156 cites W2000576209 @default.
• W1744050156 cites W2003509125 @default.
• W1744050156 cites W2031441428 @default.
• W1744050156 cites W2037791152 @default.
• W1744050156 cites W2064511898 @default.
• W1744050156 cites W2067553572 @default.
• W1744050156 cites W2074182652 @default.
• W1744050156 cites W2099725888 @default.
• W1744050156 cites W2100912832 @default.
• W1744050156 cites W2123618247 @default.
• W1744050156 cites W2160982674 @default.
• W1744050156 cites W2165948908 @default.
• W1744050156 cites W2166084034 @default.
• W1744050156 doi "https://doi.org/10.1007/s13277-015-4093-8" @default.
• W1744050156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26392110" @default.
• W1744050156 hasPublicationYear "2015" @default.
• W1744050156 type Work @default.
• W1744050156 sameAs 1744050156 @default.
• W1744050156 citedByCount "9" @default.
• W1744050156 countsByYear W17440501562016 @default.
• W1744050156 countsByYear W17440501562018 @default.
• W1744050156 countsByYear W17440501562019 @default.
• W1744050156 countsByYear W17440501562020 @default.
• W1744050156 countsByYear W17440501562023 @default.
• W1744050156 crossrefType "journal-article" @default.
• W1744050156 hasAuthorship W1744050156A5004609798 @default.
• W1744050156 hasAuthorship W1744050156A5010702785 @default.
• W1744050156 hasAuthorship W1744050156A5014807310 @default.
• W1744050156 hasAuthorship W1744050156A5020251798 @default.
• W1744050156 hasAuthorship W1744050156A5028688827 @default.
• W1744050156 hasAuthorship W1744050156A5061088955 @default.
• W1744050156 hasAuthorship W1744050156A5070180435 @default.
• W1744050156 hasConcept C104317684 @default.
• W1744050156 hasConcept C119056186 @default.
• W1744050156 hasConcept C121608353 @default.
• W1744050156 hasConcept C166703698 @default.
• W1744050156 hasConcept C16930146 @default.
• W1744050156 hasConcept C173396325 @default.
• W1744050156 hasConcept C190232843 @default.
• W1744050156 hasConcept C190283241 @default.
• W1744050156 hasConcept C2779438470 @default.
• W1744050156 hasConcept C2780580887 @default.
• W1744050156 hasConcept C502942594 @default.
• W1744050156 hasConcept C54009773 @default.
• W1744050156 hasConcept C54355233 @default.
• W1744050156 hasConcept C55493867 @default.
• W1744050156 hasConcept C555283112 @default.
• W1744050156 hasConcept C62112901 @default.
• W1744050156 hasConcept C67705224 @default.
• W1744050156 hasConcept C81885089 @default.
• W1744050156 hasConcept C86803240 @default.
• W1744050156 hasConceptScore W1744050156C104317684 @default.
• W1744050156 hasConceptScore W1744050156C119056186 @default.
• W1744050156 hasConceptScore W1744050156C121608353 @default.
• W1744050156 hasConceptScore W1744050156C166703698 @default.
• W1744050156 hasConceptScore W1744050156C16930146 @default.
• W1744050156 hasConceptScore W1744050156C173396325 @default.
• W1744050156 hasConceptScore W1744050156C190232843 @default.
• W1744050156 hasConceptScore W1744050156C190283241 @default.
• W1744050156 hasConceptScore W1744050156C2779438470 @default.
• W1744050156 hasConceptScore W1744050156C2780580887 @default.
• W1744050156 hasConceptScore W1744050156C502942594 @default.
• W1744050156 hasConceptScore W1744050156C54009773 @default.
• W1744050156 hasConceptScore W1744050156C54355233 @default.
• W1744050156 hasConceptScore W1744050156C55493867 @default.
• W1744050156 hasConceptScore W1744050156C555283112 @default.
• W1744050156 hasConceptScore W1744050156C62112901 @default.
• W1744050156 hasConceptScore W1744050156C67705224 @default.
• W1744050156 hasConceptScore W1744050156C81885089 @default.
• W1744050156 hasConceptScore W1744050156C86803240 @default.
• W1744050156 hasIssue "2" @default.
• W1744050156 hasLocation W17440501561 @default.
• W1744050156 hasLocation W17440501562 @default.
• W1744050156 hasOpenAccess W1744050156 @default.
• W1744050156 hasPrimaryLocation W17440501561 @default.
• W1744050156 hasRelatedWork W2000149980 @default.
• W1744050156 hasRelatedWork W2039201715 @default.
• W1744050156 hasRelatedWork W2067457920 @default.
• W1744050156 hasRelatedWork W2330596760 @default.
• W1744050156 hasRelatedWork W2357536123 @default.
• W1744050156 hasRelatedWork W2380850369 @default.
• W1744050156 hasRelatedWork W2383922415 @default.
• W1744050156 hasRelatedWork W2417294711 @default.

• next