Matches in SemOpenAlex for { <https://semopenalex.org/work/W1744280301> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1744280301 endingPage "251" @default.
- W1744280301 startingPage "245" @default.
- W1744280301 abstract "We have shown hypertrophic cerebrovascular remodelling in the Goto-Kakizaki (GK) rat model of diabetes. This study tested the hypotheses that (1) vascular remodelling develops as the disease progresses and alters myogenic reactivity of resistance vessels important for regulation of cerebral blood flow (CBF), and (2) glycaemic control prevents cerebrovascular remodelling and myogenic dysfunction.Middle cerebral artery (MCA) lumen diameter, media : lumen (M : L) ratio, cross-sectional area (CSA) and myogenic tone were measured in 10- and 18-week-old control Wistar and diabetic GK rats using pressurized arteriograph (n = 8-14/group). Mean arterial blood pressure (MAP) was measured with telemetry (n = 5/group). Additional GK rats were treated with metformin (300 mg kg(-1) day(-1) ) for glycaemic control starting at 7 weeks after the onset of diabetes until 18 weeks (n = 9).In the control group, there was no difference in remodelling indices, myogenic tone or MAP between ages. Eighteen week diabetic rats displayed increased M : L ratio and CSA, but decreased lumen diameter and myogenic tone compared to 10-week GK or 18-week control rats. MAP increased starting around 10 weeks of age and remained slightly higher in the GK rats. Glycaemic control normalized M : L ratio, CSA, lumen diameter and myogenic tone with no effect on blood pressure.These findings suggest that diabetic rats develop MCA remodelling as the disease progresses but this is associated with impaired myogenic reactivity which may ultimately affect CBF. Our results also provide evidence that glycaemic control is an effective therapeutic strategy to prevent cerebrovascular remodelling and dysfunction." @default.
- W1744280301 created "2016-06-24" @default.
- W1744280301 creator A5028569732 @default.
- W1744280301 creator A5070439266 @default.
- W1744280301 creator A5072730832 @default.
- W1744280301 creator A5082931259 @default.
- W1744280301 date "2011-01-27" @default.
- W1744280301 modified "2023-10-13" @default.
- W1744280301 title "Pressure-independent cerebrovascular remodelling and changes in myogenic reactivity in diabetic Goto-Kakizaki rat in response to glycaemic control" @default.
- W1744280301 cites W1977103029 @default.
- W1744280301 cites W1988644337 @default.
- W1744280301 cites W1993314312 @default.
- W1744280301 cites W1995957214 @default.
- W1744280301 cites W1999064407 @default.
- W1744280301 cites W2046409398 @default.
- W1744280301 cites W2052716928 @default.
- W1744280301 cites W2057488274 @default.
- W1744280301 cites W2060979316 @default.
- W1744280301 cites W2075832053 @default.
- W1744280301 cites W2080042922 @default.
- W1744280301 cites W2106507841 @default.
- W1744280301 cites W2117324883 @default.
- W1744280301 cites W2118411978 @default.
- W1744280301 cites W2120786848 @default.
- W1744280301 cites W2127521475 @default.
- W1744280301 cites W2147537676 @default.
- W1744280301 cites W2181092548 @default.
- W1744280301 doi "https://doi.org/10.1111/j.1748-1716.2010.02230.x" @default.
- W1744280301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3734544" @default.
- W1744280301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21092073" @default.
- W1744280301 hasPublicationYear "2011" @default.
- W1744280301 type Work @default.
- W1744280301 sameAs 1744280301 @default.
- W1744280301 citedByCount "34" @default.
- W1744280301 countsByYear W17442803012012 @default.
- W1744280301 countsByYear W17442803012013 @default.
- W1744280301 countsByYear W17442803012014 @default.
- W1744280301 countsByYear W17442803012015 @default.
- W1744280301 countsByYear W17442803012016 @default.
- W1744280301 countsByYear W17442803012017 @default.
- W1744280301 countsByYear W17442803012018 @default.
- W1744280301 countsByYear W17442803012019 @default.
- W1744280301 countsByYear W17442803012020 @default.
- W1744280301 crossrefType "journal-article" @default.
- W1744280301 hasAuthorship W1744280301A5028569732 @default.
- W1744280301 hasAuthorship W1744280301A5070439266 @default.
- W1744280301 hasAuthorship W1744280301A5072730832 @default.
- W1744280301 hasAuthorship W1744280301A5082931259 @default.
- W1744280301 hasBestOaLocation W17442803012 @default.
- W1744280301 hasConcept C126322002 @default.
- W1744280301 hasConcept C131631996 @default.
- W1744280301 hasConcept C134018914 @default.
- W1744280301 hasConcept C158846371 @default.
- W1744280301 hasConcept C164705383 @default.
- W1744280301 hasConcept C2776452961 @default.
- W1744280301 hasConcept C2777953023 @default.
- W1744280301 hasConcept C2992686903 @default.
- W1744280301 hasConcept C555293320 @default.
- W1744280301 hasConcept C58336856 @default.
- W1744280301 hasConcept C71924100 @default.
- W1744280301 hasConcept C84393581 @default.
- W1744280301 hasConcept C99322962 @default.
- W1744280301 hasConceptScore W1744280301C126322002 @default.
- W1744280301 hasConceptScore W1744280301C131631996 @default.
- W1744280301 hasConceptScore W1744280301C134018914 @default.
- W1744280301 hasConceptScore W1744280301C158846371 @default.
- W1744280301 hasConceptScore W1744280301C164705383 @default.
- W1744280301 hasConceptScore W1744280301C2776452961 @default.
- W1744280301 hasConceptScore W1744280301C2777953023 @default.
- W1744280301 hasConceptScore W1744280301C2992686903 @default.
- W1744280301 hasConceptScore W1744280301C555293320 @default.
- W1744280301 hasConceptScore W1744280301C58336856 @default.
- W1744280301 hasConceptScore W1744280301C71924100 @default.
- W1744280301 hasConceptScore W1744280301C84393581 @default.
- W1744280301 hasConceptScore W1744280301C99322962 @default.
- W1744280301 hasIssue "1" @default.
- W1744280301 hasLocation W17442803011 @default.
- W1744280301 hasLocation W17442803012 @default.
- W1744280301 hasLocation W17442803013 @default.
- W1744280301 hasLocation W17442803014 @default.
- W1744280301 hasOpenAccess W1744280301 @default.
- W1744280301 hasPrimaryLocation W17442803011 @default.
- W1744280301 hasRelatedWork W1591248362 @default.
- W1744280301 hasRelatedWork W1938009565 @default.
- W1744280301 hasRelatedWork W1993608846 @default.
- W1744280301 hasRelatedWork W2023289953 @default.
- W1744280301 hasRelatedWork W2047839432 @default.
- W1744280301 hasRelatedWork W2129817942 @default.
- W1744280301 hasRelatedWork W2145691355 @default.
- W1744280301 hasRelatedWork W2193897216 @default.
- W1744280301 hasRelatedWork W2321829922 @default.
- W1744280301 hasRelatedWork W2948744573 @default.
- W1744280301 hasVolume "203" @default.
- W1744280301 isParatext "false" @default.
- W1744280301 isRetracted "false" @default.
- W1744280301 magId "1744280301" @default.
- W1744280301 workType "article" @default.