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• W1745203445 abstract "Summary: Purpose: Long echo time (TE) spectroscopy reliably identifies the epileptogenic hippocampus in mesial temporal lobe epilepsy. Short‐TE spectroscopy gives additional metabolic information but may have more artifacts. The aim of this study was to test (a) lateralization of the seizure focus by short‐TE spectroscopy, and (b) value of myoinositol (MI) in the identification of the epileptogenic hippocampus. Methods: Twenty‐four patients with temporal lobe epilepsy: 16 with mesial temporal sclerosis (TLE‐MTS), eight patients with normal magnetic resonance imaging (MRI; TLE‐No), and 16 controls were studied with hippocampal 2D short‐TE magnetic resonance spectroscopic imaging (MRSI). Results: In TLE‐MTS, the ipsilateral N ‐acetylaspartate (NAA) was decreased compared with contralateral (p = 0.03) or controls (p = 0.007) . Additionally, the ipsilateral MI was decreased compared with controls (p = 0.012) . TLE‐No values showed no side differences and were not different from controls. Abnormalities in the anterior hippocampus correctly lateralized the epileptogenic hippocampus in ≤82% of TLE‐MTS and in ≤80% of the TLE‐No. Conclusions: The accuracy of short‐TE MRSI at 1.5 T for focus lateralization in mTLE is comparable to that of long‐TE MRSI. MI might be helpful for focus lateralization, but more information about the factors influencing the MI concentration is needed." @default.
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• W1745203445 date "2003-06-19" @default.
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• W1745203445 title "Spectroscopic Metabolic Abnormalities in mTLE with and without MRI Evidence for Mesial Temporal Sclerosis Using Hippocampal Short-TE MRSI" @default.
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• W1745203445 doi "https://doi.org/10.1046/j.1528-1157.2003.50202.x" @default.
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