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- W174522908 abstract "This chapter reviews the studies done with Escherichia coli-derived recombinant granulocyte–macrophage (GM)-colony-stimulating factors (CSF) (rHuGM-CSF), which present evidence of reversal of neutropenic states and determine whether this reversal leads to clinically relevant patient benefits. The use of human recombinant granulocyte–macrophage-colony-stimulating factors has resulted in patient benefit as shown by reduced infections (myelodysplastic syndrome, aplastic anemia), reduced days in intensive care (autologous bone marrow transplant), better adherence to cancer chemotherapy protocols, and the ability to use full doses of antiviral drugs in AIDS and cytomegalovirus retinitis. The adverse reactions are significant when high doses are used and therefore, high doses should be avoided—there is a plateau in the dose-effective biological responses. At recommended doses, GM-CSF is well-tolerated and is a valuable adjunctive therapy in the management of patients with conditions of dysmyelopoiesis and myeloid hypoplasia associated with myelotoxic therapy or after bone marrow transplantation." @default.
- W174522908 created "2016-06-24" @default.
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- W174522908 date "1993-01-01" @default.
- W174522908 modified "2023-09-26" @default.
- W174522908 title "Clinical Experience with Escherichia coli rHuGM-CSF" @default.
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- W174522908 doi "https://doi.org/10.1016/b978-0-12-364935-5.50020-1" @default.
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