Matches in SemOpenAlex for { <https://semopenalex.org/work/W174553207> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W174553207 endingPage "8" @default.
- W174553207 startingPage "552" @default.
- W174553207 abstract "The WT 1 gene has been isolated as a tumor suppressor gene of Wilms' tumor. Using reverse transcriptase-polymerase chain reaction (RT-PCR), relative levels of the WT 1 gene expression was examined in 87 patients with acute leukemia, 25 with chronic myelogenous leukemia (CML), and 24 with non-Hodgkin's lymphoma (NHL). Significant levels of the WT 1 gene were expressed in all leukemia patients, and for CML the levels increased as the clinical phase progressed. No point mutations were found in the WT 1 gene when samples from 15 acute leukemia patients were subjected to PCR single-strand conformation polymorphism analysis. In striking contrast to acute leukemia, the levels of WT1 gene expression for NHL were significantly low or even undetectable. The levels of WT 1 gene expression inversely correlated with the prognosis of acute leukemia. The quantification of the WT 1 gene expression made it possible to detect minimal residual disease (MRD) in acute leukemia regardless of the presence of absence of tumor-specific DNA markers. Simultaneous monitoring of MRD by RT-PCR using primers for specific DNA markers in four patients (two AML-M3 with PML/RAR-alpha, one AML-M2 with AML1/ETO, and one CML with bcr/abl) detected MRD comparable to that obtained from quantitation of WT 1 gene expression. In a patient with acute promyelocytic leukemia, the limits of leukemic cell detection by RT-PCR using either WT 1 or PML/RAR-alpha gene primers were 10(-3)-10(-4) and 10(-4) for bone marrow, and 10(-5) and 10(-4) for peripheral blood, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W174553207 created "2016-06-24" @default.
- W174553207 creator A5039271936 @default.
- W174553207 creator A5087055892 @default.
- W174553207 date "1995-06-01" @default.
- W174553207 modified "2023-09-23" @default.
- W174553207 title "[WT 1 and leukemia]." @default.
- W174553207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7643450" @default.
- W174553207 hasPublicationYear "1995" @default.
- W174553207 type Work @default.
- W174553207 sameAs 174553207 @default.
- W174553207 citedByCount "3" @default.
- W174553207 countsByYear W1745532072016 @default.
- W174553207 crossrefType "journal-article" @default.
- W174553207 hasAuthorship W174553207A5039271936 @default.
- W174553207 hasAuthorship W174553207A5087055892 @default.
- W174553207 hasConcept C104317684 @default.
- W174553207 hasConcept C111441629 @default.
- W174553207 hasConcept C125418893 @default.
- W174553207 hasConcept C126322002 @default.
- W174553207 hasConcept C153911025 @default.
- W174553207 hasConcept C170493617 @default.
- W174553207 hasConcept C203014093 @default.
- W174553207 hasConcept C2776601000 @default.
- W174553207 hasConcept C2776863199 @default.
- W174553207 hasConcept C2776960273 @default.
- W174553207 hasConcept C2778461978 @default.
- W174553207 hasConcept C2778729363 @default.
- W174553207 hasConcept C2779823535 @default.
- W174553207 hasConcept C2780007613 @default.
- W174553207 hasConcept C2781121885 @default.
- W174553207 hasConcept C42362537 @default.
- W174553207 hasConcept C49105822 @default.
- W174553207 hasConcept C502942594 @default.
- W174553207 hasConcept C54355233 @default.
- W174553207 hasConcept C71924100 @default.
- W174553207 hasConcept C86803240 @default.
- W174553207 hasConceptScore W174553207C104317684 @default.
- W174553207 hasConceptScore W174553207C111441629 @default.
- W174553207 hasConceptScore W174553207C125418893 @default.
- W174553207 hasConceptScore W174553207C126322002 @default.
- W174553207 hasConceptScore W174553207C153911025 @default.
- W174553207 hasConceptScore W174553207C170493617 @default.
- W174553207 hasConceptScore W174553207C203014093 @default.
- W174553207 hasConceptScore W174553207C2776601000 @default.
- W174553207 hasConceptScore W174553207C2776863199 @default.
- W174553207 hasConceptScore W174553207C2776960273 @default.
- W174553207 hasConceptScore W174553207C2778461978 @default.
- W174553207 hasConceptScore W174553207C2778729363 @default.
- W174553207 hasConceptScore W174553207C2779823535 @default.
- W174553207 hasConceptScore W174553207C2780007613 @default.
- W174553207 hasConceptScore W174553207C2781121885 @default.
- W174553207 hasConceptScore W174553207C42362537 @default.
- W174553207 hasConceptScore W174553207C49105822 @default.
- W174553207 hasConceptScore W174553207C502942594 @default.
- W174553207 hasConceptScore W174553207C54355233 @default.
- W174553207 hasConceptScore W174553207C71924100 @default.
- W174553207 hasConceptScore W174553207C86803240 @default.
- W174553207 hasIssue "6" @default.
- W174553207 hasLocation W1745532071 @default.
- W174553207 hasOpenAccess W174553207 @default.
- W174553207 hasPrimaryLocation W1745532071 @default.
- W174553207 hasRelatedWork W174553207 @default.
- W174553207 hasRelatedWork W2005428520 @default.
- W174553207 hasRelatedWork W2153382436 @default.
- W174553207 hasRelatedWork W2161493889 @default.
- W174553207 hasRelatedWork W2353645370 @default.
- W174553207 hasRelatedWork W2360105106 @default.
- W174553207 hasRelatedWork W2462889948 @default.
- W174553207 hasRelatedWork W2465625806 @default.
- W174553207 hasRelatedWork W2914915027 @default.
- W174553207 hasRelatedWork W2282386285 @default.
- W174553207 hasVolume "36" @default.
- W174553207 isParatext "false" @default.
- W174553207 isRetracted "false" @default.
- W174553207 magId "174553207" @default.
- W174553207 workType "article" @default.