Matches in SemOpenAlex for { <https://semopenalex.org/work/W1745534060> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W1745534060 endingPage "625" @default.
- W1745534060 startingPage "619" @default.
- W1745534060 abstract "Muscarinic receptors regulate a number of important basic physiologic functions including heart rate and motor and sensory control as well as more complex behaviors including arousal, memory, and learning. Loss of muscarinic receptor number or function has been implicated in the etiology of several neurological disorders including Alzheimer's dementia, Down's syndrone, and Parkinson's disease. Muscarinic receptors transduce their signals by coupling with G-proteins, which then modulate the activity of a number of effector enzymes and ion channels. Five subtypes of muscarinic receptors (m1-m5) have been identified by molecular cloning and much has been learned about their distribution, pharma-cology, and structure. Less is known about the molecular mechanisms of receptor-effector coupling and the biological role of each receptor subtype. The ectopic expression of genes encoding a single muscarinic receptor subtype in mammalian cell lines has provided an important model system in which to investigate receptor subtype-specific pharmacology and signal transduction. Expression models have revealed that single muscarinic receptor m1, m3, or m5 subtypes can activate multiple signaling effectors simultaneously including phospholipases A2, C, and D, as well as tyrosine kinase and a novel class of voltage- insensitive calcium channels. The m2 or m4 receptors have been shown to augment phospholipase A2 in addition to their established role as inhibitory receptors acting through the attenuation of adenylate cyclase. In addition to allowing investigations of the regulatory mechanisms of muscarinic receptors, expression models provide an excellent tool to investigate receptor-subtype specific physiology and pharmacology.—Felder, C. C. Muscarinic acetylcholine receptors: signal transduction through multiple effectors. FASEB J. 9, 619-625 (1995)" @default.
- W1745534060 created "2016-06-24" @default.
- W1745534060 creator A5013032842 @default.
- W1745534060 date "1995-05-01" @default.
- W1745534060 modified "2023-10-11" @default.
- W1745534060 title "Muscarinic acetylcholine receptors: signal transduction through multiple effectors" @default.
- W1745534060 doi "https://doi.org/10.1096/fasebj.9.8.7768353" @default.
- W1745534060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7768353" @default.
- W1745534060 hasPublicationYear "1995" @default.
- W1745534060 type Work @default.
- W1745534060 sameAs 1745534060 @default.
- W1745534060 citedByCount "486" @default.
- W1745534060 countsByYear W17455340602012 @default.
- W1745534060 countsByYear W17455340602013 @default.
- W1745534060 countsByYear W17455340602014 @default.
- W1745534060 countsByYear W17455340602015 @default.
- W1745534060 countsByYear W17455340602016 @default.
- W1745534060 countsByYear W17455340602017 @default.
- W1745534060 countsByYear W17455340602018 @default.
- W1745534060 countsByYear W17455340602019 @default.
- W1745534060 countsByYear W17455340602020 @default.
- W1745534060 countsByYear W17455340602021 @default.
- W1745534060 countsByYear W17455340602022 @default.
- W1745534060 countsByYear W17455340602023 @default.
- W1745534060 crossrefType "journal-article" @default.
- W1745534060 hasAuthorship W1745534060A5013032842 @default.
- W1745534060 hasConcept C116289061 @default.
- W1745534060 hasConcept C169760540 @default.
- W1745534060 hasConcept C170493617 @default.
- W1745534060 hasConcept C185592680 @default.
- W1745534060 hasConcept C207723603 @default.
- W1745534060 hasConcept C33789571 @default.
- W1745534060 hasConcept C47488739 @default.
- W1745534060 hasConcept C55493867 @default.
- W1745534060 hasConcept C62478195 @default.
- W1745534060 hasConcept C64123433 @default.
- W1745534060 hasConcept C64615621 @default.
- W1745534060 hasConcept C86803240 @default.
- W1745534060 hasConcept C95444343 @default.
- W1745534060 hasConceptScore W1745534060C116289061 @default.
- W1745534060 hasConceptScore W1745534060C169760540 @default.
- W1745534060 hasConceptScore W1745534060C170493617 @default.
- W1745534060 hasConceptScore W1745534060C185592680 @default.
- W1745534060 hasConceptScore W1745534060C207723603 @default.
- W1745534060 hasConceptScore W1745534060C33789571 @default.
- W1745534060 hasConceptScore W1745534060C47488739 @default.
- W1745534060 hasConceptScore W1745534060C55493867 @default.
- W1745534060 hasConceptScore W1745534060C62478195 @default.
- W1745534060 hasConceptScore W1745534060C64123433 @default.
- W1745534060 hasConceptScore W1745534060C64615621 @default.
- W1745534060 hasConceptScore W1745534060C86803240 @default.
- W1745534060 hasConceptScore W1745534060C95444343 @default.
- W1745534060 hasIssue "8" @default.
- W1745534060 hasLocation W17455340601 @default.
- W1745534060 hasLocation W17455340602 @default.
- W1745534060 hasOpenAccess W1745534060 @default.
- W1745534060 hasPrimaryLocation W17455340601 @default.
- W1745534060 hasRelatedWork W1564402858 @default.
- W1745534060 hasRelatedWork W1972958653 @default.
- W1745534060 hasRelatedWork W1991634597 @default.
- W1745534060 hasRelatedWork W1999663284 @default.
- W1745534060 hasRelatedWork W2000618992 @default.
- W1745534060 hasRelatedWork W2000801970 @default.
- W1745534060 hasRelatedWork W2014913952 @default.
- W1745534060 hasRelatedWork W2023374499 @default.
- W1745534060 hasRelatedWork W3144716053 @default.
- W1745534060 hasRelatedWork W657142851 @default.
- W1745534060 hasVolume "9" @default.
- W1745534060 isParatext "false" @default.
- W1745534060 isRetracted "false" @default.
- W1745534060 magId "1745534060" @default.
- W1745534060 workType "article" @default.