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• W1746448801 abstract "Abstract: This study was designed to investigate the role of opioid receptors, gamma‐aminobutyric acid (GABA) receptors, mast cells and histamine receptors (H 1 subtype) in the seizurogenic effect of amisulpride on mice. A single injection of amisulpride (180 mg/kg) was employed to evaluate the seizurogenicity of the drug in mice. Seizures were assessed in terms of a composite seizure severity score (SSS), time of the onset of straub‐like tail, onset of jerky movements of whole body, convulsions and death. Amisulpride administration (180 mg/kg) induced a significant pro‐convulsant effect in mice as measured in terms of the SSS (21.12 ± 2.71) and a significant decrease in the time latency of the onset of straub‐like tail (132.45 ± 12.31), jerky movements of whole body (153.28 ± 14.12), convulsions (184.97 ± 13.11) and death (100%). Moreover, prior administration of naloxone, cetrizine, sodium cromoglycate and gabapentin, respectively, attenuated this seizurogenic activity that amisulpride exerted on mice ( p < 0.05). Therefore, it may be suggested that amisulpride exerts a seizurogenic effect on mice possibly via an opioid receptor activation‐dependent release of histamine from the mast cells and a simultaneous inhibition of GABA release." @default.
• W1746448801 created "2016-06-24" @default.
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• W1746448801 date "2010-12-22" @default.
• W1746448801 modified "2023-10-16" @default.
• W1746448801 title "Amisulpride-Induced Seizurogenic Effect: A Potential Role of Opioid Receptor-Linked Transduction Systems" @default.
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• W1746448801 doi "https://doi.org/10.1111/j.1742-7843.2010.00655.x" @default.
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